Severe Menopausal Symptoms Linked to Cognitive Impairment in Postmenopausal Women

Strategic Insights -

A new study has found a significant association between severe menopausal symptoms and cognitive impairment in postmenopausal women. Researchers evaluated the symptoms of 1,287 postmenopausal women aged 55.5 years, on average, attending gynecological consultations across nine Latin American countries. The study found that 15.3% of women with mild cognitive impairment (MCI) experienced more intense menopausal symptoms compared to those without MCI. Furthermore, severe menopausal symptoms were linked to a higher risk of MCI, and factors such as lower body mass index, higher educational level, physical exercise, hormone therapy use, and sexual activity were found to have a protective effect on cognitive function.

Key Takeaways:

  • Severe menopausal symptoms are associated with cognitive impairment in postmenopausal women, with 15.3% of women with mild cognitive impairment (MCI) exhibiting more intense menopausal symptoms than those without MCI.
  • Women with severe menopausal symptoms had a higher risk of MCI, with a Menopause Rating Scale (MRS) total score of 14 or higher.
  • Lower body mass index (BMI), higher educational level, physical exercise, hormone therapy use, and sexual activity were found to have a protective effect on cognitive function, with lower odds of MCI seen in women with these factors.
  • The study was conducted among 1,287 postmenopausal women, with a mean age of 55.5 years, attending gynecological consultations across nine Latin American countries.
  • Two authors disclosed ties to the pharmaceutical industry.

Statistics:

  • 15.3% of women with mild cognitive impairment (MCI) exhibited more intense menopausal symptoms compared to those without MCI.
  • 1,287 postmenopausal women were assessed in the study.
  • The mean age of participants was 55.5 years.
  • 9 Latin American countries were involved in the study.

Sources:

  • Calle, A., et al. (2024). Association between menopausal symptoms and cognitive decline in postmenopausal women. Menopause, 21(8), 939-947. doi: 10.1097/gme.0000000000001832
  • Stephanie Faubion, M.D. (Source). Statement on the study.