University of South Australia Researchers Investigate Genetic Risk of Multiple Sclerosis

Strategic Insights -

Researchers at the University of South Australia are studying the biology behind multiple sclerosis (MS) to predict genetic risk of developing the disease, potentially leading to early detection and prevention. Funded by an MS Australia Incubator Grant, the study will use a powerful new research method called 'recall by genotype' to explore genetic causes of MS. The study aims to understand the link between MS and the Epstein-Barr virus, which is a common virus that affects up to 90% of the population.

Key Takeaways:

  • The study will use a new research method called 'recall by genotype' to explore genetic causes of MS, focusing on the link between MS and the Epstein-Barr virus.
  • The study aims to understand why some people develop MS while others do not, despite being infected with the Epstein-Barr virus.
  • Researchers will calculate MS genetic risk scores for over 1000 South Australian participants without an MS diagnosis and compare biological traits in a subset of participants with either high or low genetic risk.
  • The study hopes to identify early warning signs or biomarkers for MS and pave the way for larger investigations and future preventative strategies.
  • Researchers have been working to establish resources to enable RbG studies in Australia and will tackle important ethical questions about sharing genetic risk with research participants.
  • The study involves a collaboration between the University of South Australia and the University of Adelaide, with the aim of delivering globally relevant research, innovative teaching, and an outstanding student experience.

Statistics:

  • Over 33,000 Australians are affected by MS, a chronic autoimmune disease that disrupts communication between the brain, spinal cord, and body.
  • The Epstein-Barr virus affects up to 90% of the population.
  • The study will calculate MS genetic risk scores for over 1000 South Australian participants.
  • Researchers expect to identify early warning signs or biomarkers for MS in those with a high genetic risk.

Sources:

  • Research grant from MS Australia Incubator
  • University of South Australia press release (2025)
  • Adelaide University website (2025)
  • Contact for interview: Dr David Stacey, E: David.Stacey@unisa.edu.au
  • Contact for media: Annabel Mansfield, M: +61 479 182 489, E: Annabel.Mansfield@unisa.edu.au