Barriers to Same-Day Pre-exposure Prophylaxis (PrEP) Implementation in HIV Clinics Identified

Strategic Insights -

Recent research from Northwestern University has highlighted key barriers to the implementation of same-day pre-exposure prophylaxis (PrEP) in HIV clinics, particularly in areas with high HIV prevalence. The study, conducted in partnership with the Network for Implementation Science in HIV (NISH), aimed to identify factors hindering the adoption of this effective HIV prevention tool. By analyzing data from 42 Ryan White Part A-D-funded organizations in seven jurisdictions, the researchers pinpointed three primary pathways to delayed implementation: insurance coverage, insufficient staffing resources, and provider reticence with same-day PrEP prescribing.

Key Takeaways:

  • The study identified three pathways to delayed implementation of same-day PrEP in clinical organizations: (1) insurance coverage and insufficient staffing resources, (2) no onsite pharmacy, and (3) provider reticence and patient demand/(dis)interest.
  • The three pathways explained approximately 67% of clinical organizations not currently implementing same-day PrEP, with a consistency of 80%.
  • The study's findings suggest that addressing these barriers through federal and state-level policy changes, pharmacist-led same-day PrEP implementation, or mail delivery of PrEP prescriptions could optimize the impact of same-day PrEP.
  • The research emphasizes the importance of understanding key barriers and facilitators to implementation in order to enhance and scale up the adoption of same-day PrEP in federally funded clinics in the U.S.
  • The study highlights the potential benefits of same-day PrEP, including increased biomedical prevention access and uptake.

Statistics:

  • 42 Ryan White Part A-D-funded organizations in seven priority jurisdictions participated in the study.
  • 137 individual clinics were represented in the study, with 8 clinical organizations not currently implementing same-day PrEP.
  • The final model explained approximately 67% of clinical organizations not currently implementing same-day PrEP.
  • The model had a consistency of 80%.

Sources:

  • Barriers to Same-Day Pre-exposure Prophylaxis (PrEP) Implementation in Federally Funded HIV Clinics Within High-Burden Areas of the U.S.: A Coincidence Analysis. AIDS and Behavior, 2025.
  • AIDS and Behavior. (2025). 233 Spring St, New York, NY 10013, USA. Springer|plenum Publishers. (www.springer.com; www.springerlink.com/content/1090-7165/)
  • NewsRx. (2025, October 20). Studies from Northwestern University Provide New Data on HIV/AIDS [Barriers to Same-Day Pre-exposure Prophylaxis (PrEP) Implementation in Federally Funded HIV Clinics Within High-Burden Areas of the U.S.: A Coincidence Analysis]. AIDS Weekly. p 220.