Oncological Safety and Fertility Outcomes of Controlled Ovarian Stimulation in Patients with Early-Stage Endometrial Cancer

Strategic Insights -

Recent research published in F&S Reports has provided valuable insights into the oncological safety and fertility outcomes of controlled ovarian stimulation (OS) in patients with early-stage endometrial cancer. The study, conducted at Peterborough City Hospital, aimed to evaluate the safety and efficacy of OS in patients with complex endometrial hyperplasia or early-stage endometrial carcinoma (EC) managed with levonorgestrel-releasing intrauterine system (LNG-IUS). The study found that patients who underwent OS with LNG-IUS had no significant difference in recurrence or disease upgrading compared to those who did not undergo OS. Furthermore, 54% of patients who attempted conception after OS achieved a live birth, with 3 by spontaneous conception, 1 by assisted reproductive technology, and 2 by surrogacy with own embryos.

Key Takeaways:

  • The study included 34 patients with a median age of 34 years and a body mass index of 29.6 kg/m, with 76.5% diagnosed with grade 1 EC and 73.5% seeking fertility counseling.
  • The median anti-mullerian hormone level was 22.40 pmol/L, and 11 patients underwent OS with a median peak estradiol level of 1,406 pmol/L, median of 5 oocytes retrieved, and median of 4 embryos stored.
  • There was no significant difference between patients who did and those who did not undergo OS in terms of recurrence or disease upgrading for the first 50 months after LNG-IUS placement.
  • 32.35% of patients attempted to conceive during the follow-up period, with 54% achieving a live birth.

Statistics:

  • 34 patients were included in the analysis with a median age of 34 years, body mass index of 29.6 kg/m, and 73.5% seeking fertility counseling.
  • 76.5% of patients were diagnosed with grade 1 EC, and 11 patients underwent OS with a median peak estradiol level of 1,406 pmol/L.
  • 5 patients retrieved a median of 5 oocytes, and 4 patients stored a median of 4 embryos.
  • 32.35% of patients attempted to conceive, and 54% achieved a live birth.

Sources:

  • Iliana Armata, Dept. of Obstetrics and Gynaecology, Peterborough City Hospital, Edith Cavell Campus, Bretton Gate, Peterborough, UK
  • Oncological safety and fertility outcomes of controlled ovarian stimulation in patients with early-stage endometrial cancer. F&S Reports, 2025;6(3):335-340.
  • NewsRx. Reports from Peterborough City Hospital Highlight Recent Findings in Endometrial Cancer (Oncological safety and fertility outcomes of controlled ovarian stimulation in patients with early-stage endometrial cancer). OBGYN & Reproduction Week. October 20, 2025; p 761.