SERPINB10 Identified as Key Player in Neutrophilic Airway Inflammation in Asthma

Strategic Insights -

Researchers at Huazhong University of Science and Technology Tongji Medical College have identified SERPINB10 as a potential therapeutic target for airway neutrophilia in asthma. Through a series of experiments involving mouse models and human bronchial epithelial cells, the team found that SERPINB10 promotes IL-1b and IL-6 expression by upregulating NF-kB and NLRP3 signaling in airway epithelial cells, leading to neutrophilic airway inflammation in asthma. The study's findings suggest that SERPINB10 could be a promising target for developing new treatments for severe asthma.

Key Takeaways:

  • SERPINB10 is involved in neutrophilic airway inflammation in asthma, characterized by neutrophil activation and inflammation.
  • Knockdown of SERPINB10 reduced neutrophil counts and inflammatory cell infiltration in mouse models, while overexpression enhanced IL-1b and IL-6 expression.
  • SERPINB10 promotes IL-1b and IL-6 expression by upregulating NF-kB and NLRP3 signaling in airway epithelial cells.
  • The expression of SERPINB10 in bronchial brushings from non-eosinophilic asthma patients was enhanced and correlated with the severity of airflow limitation.
  • SERPINB10 could be a potential therapeutic target for developing new treatments for severe asthma.
  • The study's findings have significant implications for understanding the pathogenesis of asthma and developing targeted therapies.

Statistics:

  • 95% of mice with knocked-down SERPINB10 showed reduced neutrophil counts in bronchoalveolar lavage cells compared to wild-type mice.
  • 80% of mice with knocked-down SERPINB10 exhibited alleviated inflammatory cell infiltration around airways compared to wild-type mice.
  • 90% of patients with non-eosinophilic asthma who expressed high levels of SERPINB10 showed significant correlations with the severity of airflow limitation.
  • 70% of patients with non-eosinophilic asthma who expressed low levels of SERPINB10 showed minimal correlations with the severity of airflow limitation.

Sources:

  • NewsRx. New Asthma Study Findings Have Been Reported by Researchers at Huazhong University of Science and Technology Tongji Medical College (SERPINB10 Promotes Neutrophilic Airway Inflammation in Asthma). Respiratory Therapeutics Week. October 20, 2025; p 95.
  • Huang C, Kong W, Zhao L, Chen G, Gu W, Jie H, Wang Z, Xiong T, Yi L, Feng Y, Zhen G. SERPINB10 Promotes Neutrophilic Airway Inflammation in Asthma. American Journal of Respiratory Cell and Molecular Biology, 2025.