Sepsis Research Uncovers Treatment-Related Effects on Hemogram-Derived Ratios

Strategic Insights -

A new study examining the effects of cytokine-filtered continuous renal replacement therapy (CRRT) on sepsis patients reveals that hemogram-derived indices, such as the neutrophil-to-lymphocyte ratio (NLR) and platelet-to-lymphocyte ratio (PLR), may reflect treatment-related effects rather than disease progression. The research, conducted at a single tertiary care center in Istanbul, Turkey, analyzed data from 93 intensive care unit patients who received cytokine-filtered CRRT between January 2020 and December 2022.

Key Takeaways:

  • The study found that PLR significantly decreased from Day 0 to Days 2 and 3 in sepsis patients undergoing cytokine-filtered CRRT.
  • NLR and PLR are sensitive to cytokine-filtered CRRT and may not accurately reflect disease progression.
  • The research suggests that careful consideration of the timing and clinical context of laboratory sampling is essential when interpreting these indices in intensive care unit settings.
  • The study's findings have implications for the diagnosis and prognosis of sepsis in critically ill patients.
  • The use of hemogram-derived indices, such as NLR and PLR, should be carefully evaluated in the context of treatment-related effects.
  • The research highlights the need for further studies to investigate the effects of CRRT on sepsis patients and the utility of hemogram-derived indices in clinical practice.

Statistics:

  • 93 intensive care unit patients were included in the study.
  • The patients received cytokine-filtered CRRT between January 2020 and December 2022.
  • PLR significantly decreased from Day 0 to Days 2 and 3 (P < 0.05).
  • The study was conducted at a single tertiary care center in Istanbul, Turkey.
  • The research has been peer-reviewed and published in the journal Medical Science Monitor.

Sources:

  • NewsRx. New Sepsis Findings from Department of Anesthesiology and Reanimation Described (Changes in Hemogram-Derived Ratios in Patients with Sepsis Undergoing Cytokine-Filtered Continuous Renal Replacement Therapy in the Intensive Care Unit: A Retrospective Single-Center Study). Health & Medicine Week. October 24, 2025; p 3670.
  • Medical Science Monitor. 2025;31. (Changes in Hemogram-Derived Ratios in Patients with Sepsis Undergoing Cytokine-Filtered Continuous Renal Replacement Therapy in the Intensive Care Unit: A Retrospective Single-Center Study).
  • Int Scientific Information, Inc, 150 Broadhollow Rd, Ste 114, Melville, NY 11747, USA (Publisher contact information for the journal Medical Science Monitor).
  • Muslum Cicek, Dept. of Anesthesiology and Reanimation, Istinye university, Istanbul, Turkey (Contact information for the study's author).