Hypertension Linked to Increased Risk of Ischemic Stroke through miR-127-3p/Akt3 Axis

Strategic Insights -

Research at Fudan University in Shanghai has uncovered a critical link between hypertension and ischemic stroke through the miR-127-3p/Akt3 axis. The study, published in the American Journal of Hypertension, reveals that patients with high expression of miR-127-3p exhibit a significantly increased risk of ischemic stroke recurrence. Further analysis shows that miR-127-3p plays a significant role in promoting inflammation, oxidative stress, and apoptosis in ischemic neuronal injury.

Key Takeaways:

  • The study involved 102 patients without ischemic stroke and 155 patients with ischemic stroke who were enrolled in the research.
  • miR-127-3p was significantly upregulated in patients with ischemic stroke and demonstrated high diagnostic value.
  • Patients with high miR-127-3p expression showed a significantly increased risk of recurrence.
  • The miR-127-3p/Akt3 axis played a critical role in the regulatory mechanisms associated with hypertension complicated by ischemic stroke.
  • The study suggests that suppressing miR-127-3p may provide a potential therapeutic strategy for preventing ischemic stroke in hypertensive patients.

Statistics:

  • 102 patients without ischemic stroke were enrolled in the research.
  • 155 patients with ischemic stroke were enrolled in the research.
  • Patients with high miR-127-3p expression exhibited a 2.5-fold increased risk of recurrence.
  • Suppression of miR-127-3p relieved its inhibitory effect on Akt3, thereby activating the neuroprotective function of Akt3.

Sources:

  • Fudan University, Department of Neurology, Jinshan Hospital, Shanghai, 201508, People's Republic of China.
  • American Journal of Hypertension, 2020, published by Oxford Univ Press, Great Clarendon St, Oxford OX2 6DP, England.
  • Nature Publishing Group, www.nature.com/; American Journal of Hypertension, www.nature.com/ajh/.