Associations of the Triglyceride-Glucose Index with Blood Pressure in Children and Adolescents

Strategic Insights -

Researchers at the Guangdong Women and Children Hospital in Guangzhou, People's Republic of China, conducted a study to investigate the relationship between the triglyceride-glucose (TyG) index and blood pressure in children and adolescents. The study, published in High Blood Pressure & Cardiovascular Prevention, aimed to explore the mediating role of body composition in this relationship. The study's findings revealed a significant association between the TyG index and systolic blood pressure, with obesity-related body fat composition partially mediating this association.

Key Takeaways:

  • The study involved 408 children aged 6-17 years in Guangdong Province, China, who underwent venous blood tests, body composition assessments, and blood pressure measurements.
  • The TyG index showed the strongest positive associations with systolic blood pressure (SBP: b = 4.49, 95% CI 2.36-6.61; P < 0.01).
  • Obesity-related body fat composition, measured by the FMI and WHR, partially mediates the association between the TyG index and SBP.
  • The study concluded that the TyG index is a recognized marker of cardiometabolic risk and that its influence on blood pressure through body composition in children and adolescents needs to be further elucidated.
  • The study's findings suggest that the TyG index may be a useful predictor of blood pressure in children and adolescents.
  • The research highlights the importance of body composition in mediating the association between the TyG index and blood pressure in children and adolescents.

Statistics:

  • 408 children aged 6-17 years participated in the study.
  • The study found a significant association between the TyG index and systolic blood pressure (SBP: b = 4.49, 95% CI 2.36-6.61; P < 0.01).
  • Obesity-related body fat composition, measured by the FMI and WHR, partially mediates the association between the TyG index and SBP (mediation analysis).

Sources:

  • High Blood Pressure & Cardiovascular Prevention, 2025.
  • NewsRx, Data on Cardiovascular Research Detailed by Researchers at Guangdong Women and Children Hospital (Associations of the Triglyceride-Glucose Index and Body Fat Composition with Blood Pressure in Children and Adolescents). Pediatrics Week. November 1, 2025; p 70.
  • Guangdong Women and Children Hospital, Guangzhou, People's Republic of China.