Pediatric Patients Undergoing Enterocystoplasty Face Higher Risk of Metabolic Disease

Strategic Insights -

Researchers have conducted a retrospective study to evaluate the risk of developing metabolic complications in pediatric patients undergoing enterocystoplasty, a surgical procedure to augment a small bladder reservoir. The study, published in Neurourology and Urodynamics, found that approximately 61% of patients developed overweight or obesity, with notable risk factors being spina bifida and undergoing enterocystoplasty before puberty.

Key Takeaways:

  • The study analyzed a cohort of 112 patients who underwent enterocystoplasty at a large pediatric tertiary center, with a median follow-up time of 5 years.
  • Approximately 61% of patients developed overweight or obesity, with the majority of cases occurring within the first year after surgery.
  • Notable risk factors for developing metabolic complications included having spina bifida and undergoing enterocystoplasty before puberty.
  • The study did not find enterocystoplasty to be a risk factor for developing overweight or obesity (HR: 1.3, 95% CI: 0.865-1.982).
  • The study's findings suggest that pediatric patients undergoing enterocystoplasty may be at higher risk of developing metabolic disease, particularly with early age at surgery and presence of spina bifida.

Statistics:

  • 61% of patients developed overweight or obesity after undergoing enterocystoplasty.
  • The median follow-up time was 5 years.
  • The study included 112 patients who underwent enterocystoplasty.
  • The hazard ratio (HR) for developing overweight or obesity was 1.3 (95% CI: 0.865-1.982).
  • The study found no significant association between enterocystoplasty and risk of overweight or obesity.

Sources:

  • NewsRx. Reports from University of Colorado Denver Describe Recent Advances in Obesity (Pediatric Patients Undergoing Enterocystoplasty and Risk of Metabolic Disease: A Single Center Retrospective Study). Pediatrics Week. November 1, 2025; p 119.
  • Neurourology and Urodynamics, 2025.
  • Pediatric Patients Undergoing Enterocystoplasty and Risk of Metabolic Disease: A Single Center Retrospective Study.