Association Between Migraine and Periodontitis Explored in New Research

Strategic Insights -

Researchers at the University of Valencia, Spain, have published a systematic review and meta-analysis of the relationship between migraine and periodontitis. According to the study, published in the European Journal of Neurology, individuals with periodontitis are 1.8 times more likely to experience migraine, with a significant association found between the two conditions. The research suggests that periodontitis, a multifactorial disease affecting the dental supporting tissues, may have systemic implications, including a potential link with migraine. The study's findings offer a promising area of research for understanding and treating both conditions.

Key Takeaways:

  • A systematic review and meta-analysis was conducted using four databases (PubMed, Web of Science, Scopus, and Embase) to investigate the relationship between periodontitis and migraine.
  • A total of 197 articles were retrieved, with 8 articles included in the review and 6 in the meta-analysis.
  • The meta-analysis showed a significant odds ratio (OR) of 1.8 with a 95% confidence interval of 1.4-2.32, indicating a 1.8 times higher likelihood of experiencing migraine in individuals with periodontitis.
  • The study did not include any information on the specific causes or mechanisms underlying the association between periodontitis and migraine.
  • The research suggests that periodontitis may have systemic implications, including a potential link with migraine.
  • Further research is needed to fully understand the relationship between periodontitis and migraine.

Statistics:

  • 1.8 times higher likelihood of experiencing migraine in individuals with periodontitis (OR 1.8, 95% CI 1.4-2.32)
  • 197 articles retrieved from four databases (PubMed, Web of Science, Scopus, and Embase)
  • 8 articles included in the review
  • 6 articles included in the meta-analysis
  • 32% of articles evaluated did not meet the inclusion criteria

Sources:

  • Association Between Migraine and Periodontitis: A Systematic Review and Meta-Analysis. European Journal of Neurology, 2025;32(10). European Journal of Neurology can be contacted at: Wiley, 111 River St, Hoboken 07030-5774, NJ, USA. (Wiley-Blackwell - www.wiley.com/; European Journal of Neurology - onlinelibrary.wiley.com/journal/10.1111/(ISSN)1468-1331)
  • NewsRx. Researchers at University of Valencia Detail Findings in Periodontitis (Association Between Migraine and Periodontitis: A Systematic Review and Meta-Analysis). Obesity & Diabetes Week. November 3, 2025; p 139.