Long-Term Outcomes of Pharmacomechanical Thrombectomy in Patients with Iliofemoral DVT

Strategic Insights -

A new study has shed light on the treatment of deep vein thrombosis (DVT) in patients with and without cancer. Researchers from the Department of Cardiovascular Surgery in Konya, Turkiye, conducted a retrospective analysis of 126 patients who received either pharmacomechanical thrombectomy (PMT) or non-vitamin K antagonist oral anticoagulants (NOACs) for iliofemoral DVT. The study found that patients who underwent PMT experienced improved long-term outcomes compared to those who received only medical therapy. Furthermore, the research highlighted the significance of treating cancer-associated DVT with PMT, which can improve the quality of life among patients with this condition.

Key Takeaways:

  • The study included 126 patients with iliofemoral DVT who received either PMT (n = 60) or NOAC therapy (n = 66).
  • PMT was associated with improved long-term outcomes in patients with iliofemoral DVT compared to those who received only medical therapy.
  • Cancer-associated DVT cases (13 patients) showed a strong positive correlation between Villalta scores measured 6 months and 1 year after DVT onset (r = 0.803, P < 0.001).
  • The Villalta scale was used to measure the severity of post-thrombotic syndrome.
  • The study concluded that PMT can improve the quality of life among patients with cancer-associated DVT.
  • Abdullah Guner and colleagues conducted the research, which was published in the Annals of Surgical Treatment and Research.
  • The study received peer review.

Statistics:

  • 126 patients were included in the study, with 60 patients receiving PMT and 66 patients receiving NOAC therapy.
  • 13 patients had cancer-associated DVT.
  • Villalta scores 6 months after DVT onset showed a strong positive correlation with those 1 year after DVT onset (r = 0.803, P < 0.001).
  • The study concluded that PMT can improve the quality of life among patients with cancer-associated DVT.

Sources:

  • Evolving treatment strategies for deep venous thrombosis: long-term outcomes of pharmacomechanical thrombectomy with exploratory analysis of a cancer-associated subgroup in a retrospective cohort study. Annals of Surgical Treatment and Research, 2025;109(4):244-251.
  • Abdullah Guner, et al. Study Findings from Department of Cardiovascular Surgery Broaden Understanding of Venous Thrombosis (Evolving treatment strategies for deep venous thrombosis: long-term outcomes of pharmacomechanical thrombectomy with exploratory analysis of a ...). Hematology Week. November 3, 2025; p 1636.