Primary Cutaneous Follicle Center Lymphoma: Socioeconomic and Clinical Prognostic Factors

Strategic Insights -

A recent study published in the Annals of Plastic Surgery investigated the demographic, socioeconomic, and clinical prognostic factors affecting overall survival in patients with primary cutaneous follicle center lymphoma (PCFCL). Researchers from Miami University analyzed data from the National Cancer Database between 2004 and 2020, identifying 1293 patients with PCFCL. The study revealed significant associations between lower overall survival and female sex, older age, higher comorbidity index, higher disease stage, lower income, nonprivate insurance, and lower education levels.

Key Takeaways:

  • The study identified 1293 patients with PCFCL in the National Cancer Database between 2004 and 2020.
  • Key factors associated with worse overall survival included lower income (P = 0.030), nonprivate insurance (P = 0.043), female sex, older age, higher comorbidity index, higher disease stage, and lower education levels.
  • The study found that patients with PCFCL who were male, Stage I, and had a Charlson-Deyo (CD) comorbidity score of 0 had better overall survival.
  • The use of multivariable Cox hazard regression models showed that lower income (HR 1.27, 95% CI 1.04-1.54), nonprivate insurance (HR 1.36, 95% CI 1.06-1.74), and lower education levels (HR 1.32, 95% CI 1.05-1.65) were associated with lower overall survival.
  • The study's findings suggest that socioeconomic and clinical factors play a significant role in determining overall survival in patients with PCFCL.

Statistics:

  • 64% of patients with PCFCL were male.
  • 64% of patients with PCFCL were Stage I.
  • 50% of patients with PCFCL had a Charlson-Deyo (CD) comorbidity score of 0.
  • 24% of patients with PCFCL had lower education levels.
  • The Kaplan-Meier method showed that 5-year overall survival rates were 65.1% for patients with PCFCL, 72.3% for patients with non-private insurance, and 61.1% for patients with higher disease stage.

Sources:

  • Primary Cutaneous Follicle Center Lymphoma: Demographic, Socioeconomic, and Clinical Prognostic Factors in a National Cohort. Annals of Plastic Surgery, 2025;95(5).
  • National Cancer Database between 2004 and 2020.