Association of Triglyceride-Glucose Index with Long-Term Mortality in Patients with Depression

Strategic Insights -

A study published in Frontiers in Psychiatry has found a significant link between the triglyceride-glucose index (TyG) and long-term mortality in patients with depression. The researchers examined data from 1388 patients and found that an increase in TyG elevated the risk of 5-year all-cause mortality among depression patients. The study suggests that the dynamic fluctuations in the TyG index could potentially offer more substantial insights in identifying patients at high risk for all-cause mortality.

Key Takeaways:

  • The study found a significant association between the triglyceride-glucose index (TyG) and 5-year all-cause mortality in patients with depression.
  • The risk of long-term mortality increased with higher levels of TyG, with Quartile 4 demonstrating a 61% higher risk compared to Quartile 1.
  • The analysis results across the subgroups were consistent, with no interactions detected.
  • The study suggests that the dynamic fluctuations in the TyG index could potentially offer more substantial insights in identifying patients at high risk for all-cause mortality.
  • The researchers used a retrospective cohort study design, involving data from the MIMIC-IV database, involving 1388 patients with depression.
  • The study found a linear relationship between TyG and 5-year all-cause mortality across both the entire and matched cohorts.
  • The Kaplan-Meier curves indicated that patients with elevated TyG experienced significantly higher 5-year all-cause mortality rates in both the entire and matched cohorts.

Statistics:

  • 25.8% of the entire cohort exhibited a 5-year all-cause mortality rate.
  • The TyG and TyGVR groups had 5-year all-cause mortality rates of 23.8% and 34%, respectively.
  • The researchers found that an increase in TyG increased the 5-year all-cause mortality risk by 1.31 (95% CI, 1.1-1.56; P=0.002).
  • The risk of 5-year all-cause mortality in depression patients with elevated TyG was significantly higher in both the entire and matched cohorts (P=0.00041 and P=0.035, respectively).

Sources:

  • The association of the triglyceride-glucose index and its changes with 5-year all-cause mortality in patients with depression. Frontiers in Psychiatry, 2025;16:1672186.
  • Frontiers Media Sa, Avenue Du Tribunal Federal 34, Lausanne, Ch-1015, Switzerland.
  • Bo Xie, Dept. of Cardiology, Chengdu Integrated TCM & Western Medicine Hospital, Chengdu, People's Republic of China.