New Ultrasonics Ferroelectrics and Frequency Control Study Results Reported from University of North Carolina (UNC)

Strategic Insights -

A recent study published in the IEEE Open Journal of Ultrasonics, Ferroelectrics, and Frequency Control has presented a novel approach to interrogating the Young's elastic moduli in anisotropic media, including tissue, using Double Profile Intersection (DoPIo) ultrasound. The research, conducted by a team of scientists from the University of North Carolina (UNC), utilizes a method called Double Profile Intersection to quantify shear elasticity and longitudinal Young's modulus without relying on shear wave propagation. The study suggests that this approach may serve as a novel biomarker for characterizing elastically anisotropic tissues such as kidney, skeletal muscle, and breast.

Key Takeaways:

  • The researchers utilized Double Profile Intersection (DoPIo) ultrasound to quantify shear elasticity and longitudinal Young's modulus in anisotropic media, including tissue.
  • The study found a strong linear correlation between the rate of change of DoPIo-derived elasticity and the longitudinal Young's modulus.
  • The results suggest that DoPIo outcomes measured at normal ARF-AoS incidence are related to the shear elastic modulus alone, while variation in DoPIo-derived elasticity over ARF-AoS incidence angle exhibits a linear correlation with the longitudinal Young's modulus.
  • The study hypothesized that applying a range of ARF excitations not perpendicular to the axis of symmetry (AoS) of transversely isotropic (TI) materials and monitoring the resultant variation in DoPIo-measured elasticity versus excitation angle may allow for the interrogation of the Young's elastic moduli.
  • The research was conducted by Keita A. Yokoyama, Sabiq Muhtadi, and Caterina M. Gallippi from the University of North Carolina (UNC) at Chapel Hill.
  • The study was published in the IEEE Open Journal of Ultrasonics, Ferroelectrics, and Frequency Control in 2025.

Statistics:

  • 5:161-165 (page numbers of the published study)
  • 2025 (year of publication)
  • 5 (volume number of the journal)
  • 3 authors contributed to the study
  • The study utilized Double Profile Intersection (DoPIo) ultrasound to quantify shear elasticity and longitudinal Young's modulus
  • The study focused on anisotropic media, including tissue
  • The researchers found a strong linear correlation between the rate of change of DoPIo-derived elasticity and the longitudinal Young's modulus

Sources:

  • Double Profile Intersection (DoPIo) Ultrasound With Acoustic Radiation Force Tilting Interrogates Young's Modulus in Transversely Isotropic Media: An In Silico Study. IEEE Open Journal of Ultrasonics, Ferroelectrics, and Frequency Control, 2025;5:161-165.
  • NewsRx. New Ultrasonics Ferroelectrics and Frequency Control Study Results Reported from University of North Carolina (UNC) [Double Profile Intersection (DoPIo) Ultrasound With Acoustic Radiation Force Tilting Interrogates Young's Modulus in ...]. Electronics Newsweekly. November 4, 2025; p 261.