Advanced Lung Cancer Inflammation Index Linked to Reduced Kidney Stone Risk in Men

Strategic Insights -

Researchers from Sichuan University have published a study investigating the association between the Advanced Lung Cancer Inflammation Index (ALI) and the risk of kidney stones in adult men. The study analyzed data from the National Health and Nutrition Examination Survey (NHANES) and found that ALI scores were independently linked to a lower risk of kidney stones, especially in men without metabolic diseases.

Key Takeaways:

  • The study analyzed data from 5,429 male participants in the National Health and Nutrition Examination Survey (NHANES, 2007-2018).
  • Out of all participants, 572 (10.5%) had a history of kidney stones.
  • For every one-unit increase in ALI score, the risk of having kidney stones decreased by 22.7% (odds ratio = 0.773, 95% CI: 0.675-0.885, P < 0.001).
  • ALI scores were independently linked to a lower risk of kidney stones, especially in men without metabolic diseases.
  • As a simple inflammation and nutrition marker, ALI could help identify people who have a higher risk of kidney stones.
  • Further prospective studies are needed to validate these findings.

Statistics:

  • 10.5% of participants had a history of kidney stones (572 out of 5,429).
  • The risk of having kidney stones decreased by 22.7% for every one-unit increase in ALI score.
  • The odds ratio for the association between ALI scores and kidney stone risk was 0.773 (95% CI: 0.675-0.885, P < 0.001).

Sources:

  • The advanced lung cancer inflammation index as a predictor of kidney stone risk in men: a cross-sectional analysis. Frontiers in Nutrition, 2025 (Frontiers in Nutrition - http://www.frontiersin.org/nutrition).
  • National Health and Nutrition Examination Survey (NHANES) (2007-2018).