Alzheimer Disease Study Reveals Increased Risk of Distal Radius Fracture in Geriatric Population

Strategic Insights -

A study published in the Journal of Hand Surgery Global Online has found that Alzheimer disease is associated with a higher incidence of distal radius fracture (DRF) in the geriatric population. The researchers, from the University of Mississippi Medical Center, analyzed data from over 227 million patient records and found that patients with Alzheimer disease had a significantly higher risk of DRF compared to those with other neurodegenerative conditions.

The study, which used International Classification of Diseases 10 codes to identify neurodegenerative conditions and DRF incidence, found that Alzheimer disease was associated with a 3.5-fold increased risk of DRF compared to Parkinson disease, Huntington disease, frontotemporal dementia, Lewy body, and normal pressure hydrocephalus. The researchers concluded that Alzheimer disease may exacerbate the relationship between uncomplicated aging and diminished motor function, leading to an increased risk of falls and fractures.

Key Takeaways:

  • The study analyzed data from over 227 million patient records, making it a comprehensive nationwide study.
  • Alzheimer disease was associated with a 3.5-fold increased risk of DRF compared to other neurodegenerative conditions.
  • The study found that patients listed in the Alzheimer and Dementia Registry had an increase in DRF incidence after the age of 60 years.
  • The researchers concluded that Alzheimer disease may exacerbate the relationship between uncomplicated aging and diminished motor function.
  • The study highlights the importance of monitoring patients with Alzheimer disease for increased fall and fracture risk.

Statistics:

  • Over 227 million patient records were analyzed in the study.
  • The study found that Alzheimer disease was associated with a 3.5-fold increased risk of DRF compared to other neurodegenerative conditions.
  • The researchers calculated that 99% confidence intervals were recorded for DRF incidence.
  • The study included patients ages 60 and older.

Sources:

  • Neurodegenerative Conditions in the Geriatric Population Increase Risk of Distal Radius Fracture: A Nationwide Study. Journal of Hand Surgery Global Online, 2025,7(5):100740.
  • Mental Health Weekly Digest. October 13, 2025; p 433.