Alzheimer's Disease Research Reveals Promising Therapeutic Agent from Cremastra Appendiculata Polysaccharides

Strategic Insights -

Researchers from Sichuan Normal University have evaluated the physicochemical properties, antioxidant activity, and anti-Alzheimer's disease (AD) effects of Cremastra appendiculata polysaccharides (CAPs) in vitro and in Caenorhabditis elegans (C. elegans) AD models. The study demonstrates that CAP has potent antioxidant and anti-AD effects, alleviating amyloid-beta (A beta) and tau-induced toxicity, and may serve as a promising therapeutic agent for Alzheimer's disease.

Key Takeaways:

  • CAP, a polysaccharide extracted from Cremastra appendiculata, exhibits significant antioxidant activity, protecting PC12 cells from A beta-induced cytotoxicity.
  • In C. elegans, CAP extends lifespan, alleviates tau-induced locomotor defects, reduces A beta-induced paralysis and serotonin hypersensitivity, and decreases A beta deposition by 79.96% at 2.0 mg/mL.
  • CAP upregulates key genes in the insulin/insulin-like growth factor signaling pathway, including daf-16 and skn-1, along with their downstream targets (sod-3, ctl-1, gst-4, hsp-70).
  • The study's findings suggest that CAP may serve as a promising therapeutic agent for Alzheimer's disease.
  • CAP's stable structure, potent antioxidant activity, and ability to alleviate A beta- and tau-induced toxicity make it a potential treatment for AD.

Statistics:

  • 22.37%: The percentage of uronic acid in CAP.
  • 270 degrees C: The temperature at which CAP's stability is compromised.
  • 79.96%: The reduction in A beta deposition achieved by CAP at 2.0 mg/mL.
  • 26(8): The pagination of the study's publication in the International Journal of Molecular Sciences.
  • 2025: The year in which the study was published.

Sources:

  • cremastra Appendiculata Polysaccharides Alleviate Neurodegenerative Diseases In caenorhabditis Elegans : Targeting Amyloid-b Toxicity, Tau Toxicity and Oxidative Stress. International Journal of Molecular Sciences, 2025;26(8).
  • Sichuan Normal University, Key Lab Land Resources Evaluat & Monitoring Southw, Ministry of Education, Chengdu 610101, People's Republic of China.