Anesthetic Success Rates Improved with Combined Labial and Lingual Infiltration

Strategic Insights -

Researchers at Shiraz University of Medical Sciences in Iran conducted a clinical trial to evaluate the effectiveness of two different anesthesia techniques for the mandibular lateral incisor. The study compared the efficacy of lingual infiltration alone versus combined labial and lingual infiltration using 4% articaine with 1:100,000 epinephrine. The results showed that the combined technique produced a significantly higher success rate, sustained anesthesia, and improved anesthesia onset time.

Key Takeaways:

  • The study involved 50 healthy volunteers who received two infiltration techniques: lingual infiltration only and combined labial and lingual infiltration.
  • The combined technique produced an equal or higher success rate, significantly greater sustained anesthesia, and improved anesthesia onset time compared to lingual infiltration alone.
  • The anesthetic success was evaluated by the absence of response to maximal electronic pulp tester stimulation, sustained anesthesia defined as no response within 16 minutes lasting 42 minutes, and anesthesia onset time.
  • The research concluded that the combination of labial and lingual infiltration with 4% articaine and 1:100,000 epinephrine significantly improves the anesthetic success and duration for the mandibular lateral incisor.
  • Statistical tests used in the study included McNemar's, Wilcoxon signed-rank, Friedman, and Dunn's test.
  • The study highlights the importance of considering the location of articaine infiltration for successful mandibular lateral incisor anesthesia.

Statistics:

  • 50 healthy volunteers participated in the clinical trial.
  • The combined technique produced an equal or higher success rate (P 0.05).
  • Sustained anesthesia was significantly greater with the combined technique (P 0.05).
  • Anesthesia onset time was improved with the combined technique.
  • 170-mm Heft-Parker visual analog scale (VAS) was used to assess injection-related pain.

Sources:

  • Evaluation of articaine infiltration location on the success rate of mandibular lateral incisor anesthesia: A prospective crossover randomized clinical trial study. Journal of Endodontics, 2025.
  • NewsRx. Reports on Clinical Trial Research Findings from Shiraz University of Medical Sciences Provide New Insights (Evaluation of articaine infiltration location on the success rate of mandibular lateral incisor anesthesia: A prospective crossover ...). Clinical Trials Week. October 20, 2025; p 2332.