Association Between Triglyceride-Glucose-Body Mass Index and Cardiovascular Disease Risk in Postmenopausal Women

Strategic Insights -

Researchers at the Shandong University of Traditional Chinese Medicine have conducted a nationwide prospective cohort study to examine the association between the triglyceride-glucose-body mass (TyG-BMI) index and cardiovascular disease (CVD) risk in Chinese menopausal women. The study utilized data from the 2011 and 2020 China Health and Retirement Longitudinal Study (CHARLS) and included 2405 participants, of which 609 (25.32%) developed CVD. The study found a significant association between TyG-BMI and the risk of CVD in postmenopausal women, with each interquartile TyG-BMI increase raising CVD risk by 28%. The results suggest that TyG-BMI can be a valuable biomarker for enhancing primary prevention and management strategies in this population.

Key Takeaways:

  • The study examined the association between TyG-BMI and CVD risk in 2405 Chinese menopausal women from the 2011 and 2020 CHARLS data.
  • The study found a significant association between TyG-BMI and CVD risk, with each interquartile increase raising the risk by 28% (OR = 1.28, 95% CI: 1.07-1.53).
  • A linear dose-response relationship existed for CVD (P-trend 0.05), indicating that higher TyG-BMI values are associated with increased CVD risk.
  • Marital status modified the association between TyG-BMI and CVD risk, with no significant interactions in other subgroups.
  • TyG-BMI (AUC = 0.645) outperformed TyG (AUC = 0.622) for CVD prediction, indicating that TyG-BMI is a significant predictor of CVD risk.
  • The study found that TyG-BMI can be a valuable biomarker for enhancing primary prevention and management strategies in postmenopausal women.

Statistics:

  • 25.32% of participants (609 out of 2405) developed CVD.
  • Each interquartile TyG-BMI increase raised CVD risk by 28% (OR = 1.28, 95% CI: 1.07-1.53).
  • AUC value for TyG-BMI (AUC = 0.645) outperformed TyG (AUC = 0.622) for CVD prediction.

Sources:

  • Zhu, W., Wei, D., Yang, X., Liu, Y., Yang, J. (2025). Link between triglyceride-glucose-body mass index and future cardiovascular disease risk in Chinese menopausal women: A nationwide prospective cohort study. Experimental Gerontology, 211, 112906.
  • Pergamon-elsevier Science Ltd. (Publisher). The Boulevard, Langford Lane, Kidlington, Oxford OX5 1GB, England. (Elsevier - www.elsevier.com; Experimental Gerontology - www.journals.elsevier.com/experimental-gerontology/)