Association between Triglyceride-Glucose Index and Arteriosclerosis in Type 2 Diabetes

Strategic Insights -

A recent study published in the BMC Cardiovascular Disorders journal has uncovered a significant association between the triglyceride-glucose (TyG) index and arteriosclerosis in patients with type 2 diabetes. The research, conducted at the Third Affiliated Hospital of Soochow University, involved 410 patients with type 2 diabetes mellitus (T2DM) and revealed that the TyG index is a strong predictor of arteriosclerosis risk. The study found that patients with higher TyG levels had a significantly increased risk of arteriosclerosis, with the risk being substantially higher in the group with high TyG levels.

Key Takeaways:

  • The TyG index is significantly associated with the risk of arteriosclerosis in patients with type 2 diabetes.
  • The study involved 410 patients with type 2 diabetes mellitus (T2DM) hospitalized at the Third Affiliated Hospital of Soochow University from January 2021 to December 2023.
  • The research found that patients with higher TyG levels had a significantly increased risk of arteriosclerosis, with the risk being substantially higher in the group with high TyG levels.
  • The risk of arteriosclerosis was found to increase with higher TyG index levels, and a positive linear relationship was observed between the TyG index and arteriosclerosis.
  • The study also found that the mediating effect of ABI accounted for 10.9% of the relationship between the TyG index and arteriosclerosis.

Statistics:

  • The study involved a total of 410 patients with type 2 diabetes mellitus (T2DM).
  • The patients were divided into an arteriosclerosis group (n = 298) and a non-arteriosclerosis group (n = 112) based on brachial-ankle pulse wave velocity (ba-PWV) values.
  • The risk of arteriosclerosis was increased by 2.748 times in patients with elevated TyG levels, compared to those with normal TyG levels (95% CI: 1.442-5.237, P = 0.002).
  • The risk of arteriosclerosis was substantially higher in the group with high TyG levels (OR = 3.420, 95% CI: 1.458-8.023, P = 0.005).

Sources:

  • Association between triglyceride-glucose index and arteriosclerosis in patients with type 2 diabetes and its mediating effect. BMC Cardiovascular Disorders, 2025,25(1):1-11. (BMC Cardiovascular Disorders - http://bmccardiovascdisord.biomedcentral.com)
  • Third Affiliated Hospital of Soochow University
  • Yan Sun, Department of Nuclear Medicine, Third Affiliated Hospital of Soochow University
  • Xiaonan Shao, Xinshui Wang, Shuying Zhang