Association of PCSK9 and OLR1 Genes with Ischemic Stroke Risk in an Iranian Population

Strategic Insights -

Recent research has shed light on the genetic factors influencing the risk of ischemic stroke in an Iranian population. Epigenetic studies have identified specific genes and molecular alterations that are associated with the risk of ischemic stroke, and understanding these genetic factors can aid in stroke prevention. A case-control study enrolled 150 ischemic stroke patients and 150 healthy controls from an Iranian population and found a significant association between the E670G polymorphism of the PCSK9 gene and the K167N polymorphism of the OLR1 gene with an increased risk of ischemic stroke.

Key Takeaways:

  • The study enrolled 150 ischemic stroke patients and 150 healthy controls from an Iranian population to investigate the association between polymorphisms in the PCSK9 and OLR1 genes and the incidence of ischemic stroke.
  • Genotyping of the PCSK9 E670G and OLR1 K167N polymorphisms was performed using polymerase chain reaction (PCR) followed by restriction fragment length polymorphism (RFLP) analysis.
  • The study found that the G allele of the PCSK9 gene was significantly more prevalent in the patient group than in controls, with an odds ratio (OR) of 2.41.
  • For the OLR1 gene, the study found that the C allele was more frequent among patients compared to controls, with an OR of 1.62.
  • Significant differences were observed between the two groups regarding total cholesterol, triglycerides, LDL-C, HDL-C, and body mass index (BMI), with all comparisons yielding p-values less than 0.05.
  • The study concluded that there is a significant association between the E670G polymorphism of the PCSK9 gene and the K167N polymorphism of the OLR1 gene with an increased risk of ischemic stroke in the Iranian population studied.

Statistics:

  • Odds ratio (OR) of 2.41 for the G allele of the PCSK9 gene
  • Odds ratio (OR) of 1.62 for the C allele of the OLR1 gene
  • 139 AA, 7 AG, and 4 GG genotypes in the patient group
  • 145 AA, 3 AG, and 2 GG genotypes in the control group
  • 41, 71, and 38 frequencies of GG, GC, and CC variants in the control group, respectively
  • 30, 62, and 58 frequencies of GG, GC, and CC variants in the patient group, respectively

Sources:

  • Association of the E670G variant of the PCSK9 gene and the K167N variant of the OLR1 gene with the risk of ischemic stroke in an Iranian population. Basic and Clinical Biochemistry and Nutrition, 2025,1(3):133-139.
  • Kashan University of Medical Sciences, Kashan, Iran.
  • Mahdieh Latifi, Anatomical Sciences Research Center, Institute for Basic Science, Kashan University of Medical Sciences, Kashan, Iran.
  • Kamal Razavi-Azarkhiavi, Sepideh Etehadi Moghadam, Mohammad Ali Atlasi.