Strategic Insights

Children's Hospital (Boston, Massachusetts)

Novel Genetic Variant Expands Clinical Phenotype in Older Patient with Intellectual Disabilities

A groundbreaking case study published by researchers at Boston Children's Hospital sheds new light on the long-term prognosis of individuals with a specific genetic variant. A 71-year-old female patient with a history of intellectual disabilities, schizoaffective disorder, and psychosis was found to have a novel, heterozygous, predicted loss-of-function

Drug resistance

Tuberculosis Treatment Outcomes in South Africa: Analysis of Multidrug-Resistant Cases

Researchers from the University of KwaZulu-Natal have conducted a retrospective study to assess treatment outcomes of patients receiving the nine-month short regimen for rifampicin-resistant and multidrug-resistant tuberculosis (RR/MDR-TB) in uMkhanyakude District, South Africa. The study, published in BMC Infectious Diseases, aimed to identify socio-demographic and clinical factors associated with

Electronic records

Machine Learning Approach Monitors Impact of Computerized Clinical Decision Support Tools on Clinicians' Electronic Health Record Activities

Research from the University of Massachusetts Chan Medical School has developed and tested a novel machine learning approach to monitor the impact of computerized clinical decision support (CDS) tools on clinicians' electronic health record (EHR) activities. The approach leverages topic modeling, a latent-variable statistical machine learning method, to infer

Cancer

Multimodal Prehabilitation Improves Physical Fitness and Nutritional Status in Gynaecological Oncology Patients

A recent study from Radboud University Medical Center has investigated the effects of multimodal prehabilitation on physical fitness and nutritional status in women with gynaecological cancer. The research, published in Gynecologic Oncology, aimed to assess the impact of a prehabilitation program consisting of exercise, nutrition, psychological support, and intoxication cessation