Baseline HIV Protease Mutation Predicts 90M Mutation at Virological Failure

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Research conducted in Italy revealed a significant association between minor mutations in human immunodeficiency virus (HIV) protease at baseline and the development of common primary mutation 90M at virological failure. The study, published in the Journal of Infectious Diseases, evaluated the probability of accumulating a new 90M mutation at virological failure in 93 previously drug-naive patients who experienced failure of their first protease inhibitor-based antiretroviral regimens.

Key Takeaways:

  • The presence of minor mutation 36I at baseline was associated with a 13.5-fold increased probability of accumulating a new 90M mutation at virological failure (adjusted odds ratio, 13.5 [95% confidence interval, 1.89-95.6]; p=.009).
  • The minor mutation 10I/V was also found to potentially contribute to the appearance of 90M at virological failure.
  • Approximately 25% of HIV clade B and 80% of HIV non-clade-B viruses naturally carry the minor mutation 36I.
  • The study suggests that the presence of 36I at baseline may predict the appearance of 90M at virological failure.

Statistics:

  • 93 patients were included in the study, all of whom experienced failure of their first protease inhibitor-based antiretroviral regimens.
  • The presence of 36I at baseline was found in approximately 25% of HIV clade B and 80% of HIV non-clade-B viruses.
  • The adjusted odds ratio for the association between 36I and the accumulation of 90M mutation at virological failure was 13.5 (95% confidence interval, 1.89-95.6).

Sources:

  • Journal of Infectious Diseases (Partial citation: "Minor mutations in HIV protease at baseline and appearance of primary mutation 90M in patients for whom their first protease-inhibitor antiretroviral regimens failed. J Infec Dis, 2004;189(11):1983-1987")
  • University of Roma Tor Vergata, Department of Experimental Medicine, Via Montpellier 1, I-00133 Rome, Italy (Contact: C.F. Perno)
  • University of Chicago Press, 1427 E 60TH St., Chicago, IL 60637-2954 USA (Contact: Publisher of the Journal of Infectious Diseases)
  • Health & Medicine Week via NewsRx.com & NewsRx.net (Copyright 2004, Health & Medicine Week)