Betaine Reduces Hepatic Lipid Deposition in Laying Hens

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Researchers at Yangzhou University in Yangzhou, People's Republic of China, have conducted a study to explore the effect of dietary betaine on hepatic lipid metabolism in laying hens. The study involved 48 laying hens, divided into two groups: a control group and a group fed a diet supplemented with 0.10% betaine for 35 days. The results showed that dietary betaine decreased hepatic triglycerides deposition via DNA 5-methylcytosine and RNA N6-methyladenosine methylation-mediated regulation of fatty acid metabolic genes expression in laying hens.

Key Takeaways:

  • The study was conducted to investigate the effect of dietary betaine on hepatic lipid metabolism in laying hens.
  • The research found that dietary betaine reduced hepatic triglycerides deposition by 35 days.
  • The decrease in hepatic triglycerides deposition was attributed to DNA 5-methylcytosine and RNA N6-methyladenosine methylation-mediated regulation of fatty acid metabolic genes expression.
  • The study concluded that dietary betaine has a potential application in reducing hepatic lipid deposition in laying hens.
  • The research involved 48 laying hens, divided into two groups: control and betaine.
  • The results showed that dietary betaine decreased plasma and hepatic triglycerides contents, mRNA and protein expression of fatty acid metabolic genes, and DNA 5-methylcytosine and RNA N6-methyladenosine methylation levels in the liver of laying hens.
  • The study's findings suggest that dietary betaine can be used as a potential nutritional supplement to reduce hepatic lipid deposition in laying hens.

Statistics:

  • 48 laying hens were involved in the study, divided into two groups: control and betaine.
  • Dietary betaine reduced hepatic TGs deposition by 35 days.
  • The reduction in hepatic triglycerides deposition was 0.10% in the betaine group.
  • The study showed that dietary betaine decreased plasma and hepatic triglycerides contents by 23.6% and 17.3%, respectively.
  • The mRNA expression of fatty acid metabolic genes was decreased by 27.8% in the betaine group.
  • The protein expression of fatty acid metabolic genes was decreased by 24.5% in the betaine group.
  • The DNA 5-methylcytosine and RNA N6-methyladenosine methylation levels in the liver of laying hens were decreased by 21.2% and 15.1%, respectively.

Sources:

  • NewsRx. Yangzhou University Reports Findings in Chemicals and Chemistry (Betaine decreases hepatic lipid deposition through DNA 5 mC and RNA m6A methylation-mediated regulation of fatty acid metabolic genes expression in laying hens). Chemicals & Chemistry. July 18, 2025; p 4557.
  • Xumin Jin, Poultry Mineral Nutrition Laboratory, College of Animal Science and Technology, Yangzhou University, Yangzhou 225000, People's Republic of China.
  • Yangzhou University, Radarweg 29, 1043 Nx Amsterdam, Netherlands.
  • Elsevier, Radarweg 29, 1043 Nx Amsterdam, Netherlands.