Breakthrough in Lung Cancer Diagnosis: Ultra-Rapid Analysis within 60 Seconds

Strategic Insights -

Researchers at Shanghai Institute of Technology have made a significant advancement in the diagnosis of lung cancer using an ultra-rapid analysis method. According to their study, published in AIP Advances, the researchers developed a high-speed capillary electrophoresis system that can detect and quantify lung cancer tumor markers within 60 seconds. This innovative approach may provide a promising detection strategy for lung cancer diagnosis in the clinical field, significantly improving patient outcomes.

Key Takeaways:

  • The researchers developed a high-speed capillary electrophoresis system that can detect and quantify lung cancer tumor markers within 60 seconds.
  • The system was coupled with an ultra-short identification microchannel and a facile-to-use space domain internal standard quantification method.
  • The detection performances of the system, including reliability, accuracy, and precision, were investigated in detail.
  • The researchers successfully identified and quantified codon 249 (118 bp) and codon 248 (200 bp) of the p53 gene in an ultra-short time of 60 seconds.
  • The detected concentration of the two target samples featured a well linearity determined by the SDIS method.
  • The theoretical detection limit of the system could achieve 0.01662 and 0.05467 ng/ml for codon 249 and codon 248 fragments, respectively.
  • The study was supported by Shanghai Sailing Program, China; Collaborative Innovation Project of Shanghai Institute of Technology; Science And Technology Talent Development Fund For Young And Middle-aged Teachers of Shanghai Institute of Technology; and Ai-enabled Discipline Promotion Plan of Shanghai, China.
  • The researchers involved in this study include Yang Yu, Yanguang Ding, Yu Sun, Jing Yang, Liangjie Feng, Chang Liu, Menglong Shu, Fengchao Wang, and Jin Chen.

Statistics:

  • Detection time: 60 seconds
  • Contained fragments: codon 249 (118 bp) and codon 248 (200 bp) of the p53 gene
  • Theoretical detection limit: 0.01662 ng/ml (codon 249) and 0.05467 ng/ml (codon 248)
  • Detection performances: Reliability, accuracy, and precision
  • Study support: Shanghai Sailing Program, China; Collaborative Innovation Project of Shanghai Institute of Technology; Science And Technology Talent Development Fund For Young And Middle-aged Teachers of Shanghai Institute of Technology; Ai-enabled Discipline Promotion Plan of Shanghai, China.

Sources:

  • AIP Advances, "Ultra-rapid analysis of p53 gene for lung cancer diagnosis within 60 s." Vol. 15, No. 6 (2025), 065317-065317-7.
  • AIP Publishing LLC.
  • Health & Medicine Week, "Research from Shanghai Institute of Technology Yields New Study Findings on Lung Cancer (Ultra-rapid analysis of p53 gene for lung cancer diagnosis within 60 s)." July 18, 2025; p 4113.