Breakthrough in Nanotechnology: Development of Non-Enzymatic Electrochemical Glucose Sensor

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Researchers from the University of Mumbai have successfully developed a non-enzymatic electrochemical glucose sensor using nanoparticles. The sensor has shown high sensitivity and selectivity towards glucose, detecting concentrations as low as 0.0009 mM and quantifying up to 6.0 mM. This breakthrough has significant implications for the diagnosis and management of diabetes.

Key Takeaways:

  • The study developed alpha-Ni(OH)2@DEHP nanoparticles through the liquid-liquid interface (PELLI) method, which were characterized by FTIR, XRD, XPS, FE-SEM, and EDAX analysis.
  • The electrochemical sensor, fabricated using these nanoparticles, showed high sensitivity and selectivity towards glucose in the presence of potential intrusive biomolecules.
  • The limit of detection (LOD), the limit of quantification (LOQ), and the linear calibration range of glucose were found to be 0.0009 mM, 0.0033 mM, and 50 μM-6.0 mM, respectively.
  • The sensitivity of the sensor was 283.366 μA cm-2 mM-1.
  • The sensor was successfully used to determine low glucose concentrations in blood samples with high recovery rates.
  • The research has been peer-reviewed and published in the New Journal of Chemistry.
  • The study was conducted by a team of researchers from the University of Mumbai, led by Arun K. Kadu, with additional authors Kainat I. Shaikh, Shabnam Khatoon, Mritunjay S. Tiwari, and Suresh D. Pawar.

Statistics:

  • The limit of detection (LOD) for glucose was 0.0009 mM.
  • The limit of quantification (LOQ) for glucose was 0.0033 mM.
  • The linear calibration range for glucose was 50 μM-6.0 mM.
  • The sensitivity of the sensor was 283.366 μA cm-2 mM-1.

Sources:

  • A-ni(Oh) 2 @dehp Nanoparticles for the Fabrication of a Non-enzymatic Electrochemical Glucose Sensor. New Journal of Chemistry, 2025.
  • NewsRx. Study Findings on Nanoparticles Are Outlined in Reports from University of Mumbai [A-ni(Oh) 2 @dehp Nanoparticles for the Fabrication of a Non-enzymatic Electrochemical Glucose Sensor]. Nanotechnology Weekly. July 7, 2025; p 6054.
  • Royal Society of Chemistry. New Journal of Chemistry. Royal Soc Chemistry, Thomas Graham House, Science Park, Milton Rd, Cambridge CB4 0WF, Cambs, England. (www.rsc.org/)