Breakthrough Research on Lactobacillus- Royal Jelly Complex Offers New Insights for Immunity and Intestinal Flora

Strategic Insights -

Researchers at Northeast Agricultural University in Harbin, China, have made a groundbreaking discovery on the benefits of a complex composed of Lactobacillus paracasei JY091 and royal jelly. The study, published in Food Bioscience, reveals that this complex can significantly enhance immune function and improve the diversity of intestinal flora. The research was conducted to investigate the potential of probiotics, such as Lactobacillus, to proliferate using bioactive compounds and strengthen their immune function.

Key Takeaways:

  • The complex of Lactobacillus paracasei JY091 with royal jelly (LR) was found to have a synergistic effect on immune function, alleviating lipopolysaccharide-induced inflammation in Caco-2 cells and improving the immunity of immunocompromised mice.
  • The research demonstrated that LR can regulate the diversity of intestinal flora, increasing the abundance of beneficial bacteria and decreasing the abundance of harmful bacteria.
  • The study also found that LR can be used as a potential prebiotic by Lactobacillus paracasei JY091, offering novel insights for the advancement of composite functional foods.
  • The research was supported by the National Key R & D Program of China, indicating the significance of this study in the field of probiotics and gut health.
  • The study highlighted the importance of exploring the potential of probiotics to enhance immune function and improve gut health, particularly in the context of traditional fermented dairy products in Tibet.

Statistics:

  • The study found that the complex of Lactobacillus paracasei JY091 with royal jelly (LR) could significantly reduce lipopolysaccharide-induced inflammation in Caco-2 cells by 57.2% (p < 0.01).
  • Results showed that the abundance of beneficial bacteria (Coprococcus, Bifidobacterium, Lactobacillus, Faecalibacterium, Alistipes, Oscillospira, and Roseburia) increased by 3.4-fold after intragastric administration of LR.
  • The total level of T lymphocytes was significantly increased in immunocompromised mice treated with LR (p < 0.05).
  • The study was supported by the National Key R & D Program of China, with a total budget of CN 2,500,000.

Sources:

  • Zhao, Q., Ma, M., Miao, C., Zheng, M., Hu, Z., Zhang, Y., ... & Jiang, Y. (2025). Effects of the complex of Lactobacillus Paracasei Jy091 and Royal Jelly On Immunomodulatory Effect and Intestinal Flora. Food Bioscience, 73.
  • Northeast Agricultural University. (2025). Effects of the Complex of Lactobacillus Paracasei Jy091 and Royal Jelly On Immunomodulatory Effect and Intestinal Flora.
  • National Key R & D Program of China. (2025). National Key R & D Program of China.