Case Comprehensive Cancer Center Launches Phase 2 Trial for Liquid Nitrogen Spray Cryotherapy in Locally Advanced Esophageal Adenocarcinoma

Strategic Insights -

Case Comprehensive Cancer Center has initiated a Phase 2 clinical trial, "Study Liquid Nitrogen Spray Cryotherapy Prior To Neoadjuvant Systemic Therapy In Locally Advanced Esophageal Adenocarcinoma," to investigate the effectiveness of Liquid Nitrogen Spray Cryotherapy (LNSC) in addition to chemotherapy versus chemotherapy alone in treating esophageal adenocarcinoma. The trial, led by principal investigator Tilak Shah, MD, aims to enroll 40 participants from the USA and will be conducted in collaboration with the Salgi Foundation. This study involves comparing the outcomes of patients receiving LNSC prior to chemotherapy with those who undergo chemotherapy alone, with the goal of improving treatment efficacy for esophageal adenocarcinoma patients.

Key Takeaways:

  • The trial, "NCT07222657," is a Phase 2 interventional clinical trial aiming to study the effectiveness of LNSC prior to neoadjuvant systemic therapy in locally advanced esophageal adenocarcinoma patients.
  • The study is designed to randomize participants into two groups: one receiving LNSC as part of their treatment and the other undergoing standard chemotherapy alone.
  • The LNSC device is an FDA-approved device that uses liquid nitrogen to rapidly cool cancerous tissue, causing cell damage.
  • The trial plans to enroll 40 participants from the USA and is expected to last approximately 4 months.
  • The primary objective of the study is to determine whether the addition of LNSC to chemotherapy improves treatment outcomes for locally advanced esophageal adenocarcinoma patients.
  • The trial is being conducted in collaboration with the Salgi Foundation, and the principal investigator is Tilak Shah, MD.

Statistics:

  • 40 participants are expected to participate in the trial from the USA.
  • The study is designed to span approximately 4 months.
  • The trial aims to investigate the effectiveness of LNSC in combination with chemotherapy versus chemotherapy alone in treating locally advanced esophageal adenocarcinoma.

Sources:

  • ClinicalTrials.gov
  • Contify.com