COVID-19 Severity Linked to Mannose-Binding Lectin Gene Polymorphisms in Children

Strategic Insights -

New research on the Coronavirus - COVID-19 has shed light on the potential role of mannose-binding lectin (MBL) gene polymorphisms in determining the clinical severity of COVID-19 in children. According to the study, published in Molecular Biology Reports, the MBL2 gene polymorphisms, particularly in the exon-1 region, were associated with the symptomatic course of COVID-19 in pediatric patients. The research suggested that codon 54 polymorphism in the MBL2 gene exon-1 region can be linked to the symptomatic course of COVID-19.

Key Takeaways:

  • A total of 100 children with COVID-19 were included in the study, with a mean age of 130 ± 67.2 months.
  • 68 (68%) of the patients were symptomatic, while 32 (32%) were asymptomatic.
  • The polymorphisms in the -221nt and -550nt promoter regions did not differ between the symptomatic and asymptomatic groups.
  • The AB and BB genotypes of codon 54 were more frequently detected in symptomatic patients (45.6% and 9.4%, respectively) than in asymptomatic patients (23.5% and 6.3%, respectively).
  • The study concluded that codon 54 polymorphism in the MBL2 gene exon-1 region can be associated with the symptomatic course of COVID-19.

Statistics:

  • 100 children were included in the study.
  • The mean age of the patients was 130 ± 67.2 months.
  • 68 (68%) of the patients were symptomatic, while 32 (32%) were asymptomatic.
  • The frequency of AB genotype was 45.6% in symptomatic patients and 23.5% in asymptomatic patients.
  • The frequency of BB genotype was 9.4% in symptomatic patients and 6.3% in asymptomatic patients.

Sources:

  • NewsRx. Izmir Katip Celebi University Reports Findings in COVID-19 (Association between mannose binding lectin gene polymorphisms and clinical severity of COVID-19 in children). Pediatrics Week. June 17, 2023; p 9.
  • Association between mannose binding lectin gene polymorphisms and clinical severity of COVID-19 in children. Molecular Biology Reports, 2023.
  • Izmir Katip Celebi University. Molecular Biology Reports. Springer, Van Godewijckstraat 30, 3311 Gz Dordrecht, Netherlands.