Deep Vein Thrombosis Study Reveals New Insights into Risk Factors

Strategic Insights -

A recent study published by researchers at Udayana University has shed new light on the risk factors associated with deep vein thrombosis (DVT) in patients with malignancy receiving platinum-based chemotherapy. The researchers found that high levels of soluble P-selectin, neutrophil extracellular traps (NET), and myeloperoxidase (MPO) are risk factors for DVT in this patient group. Specifically, the study found that high soluble P-selectin levels (OR 3.38, CI 1.180 - 9.780, p=0.02) and high NET levels (OR 2.88, CI 1.026-8.074, p=0.04) were associated with an increased risk of DVT.

Key Takeaways:

  • The study found that high levels of soluble P-selectin, NET, and MPO are risk factors for DVT in patients with malignancy receiving platinum-based chemotherapy.
  • The study used a case-control design, with 31 subjects in each case and control groups.
  • The mean age of the case group was 50.26±12.15 years, while the mean age of the control group was 52.81±11.64 years.
  • Most subjects in both groups were female (71% in the case group and 71% in the control group).
  • Carboplatin was the most commonly used chemotherapy agent in both groups (71% in the case group and 71% in the control group).
  • Cervix malignancy was the most common malignancy in the case group (32.3%), while nasopharyngeal malignancy was the most common in the control group (25.8%).
  • High soluble P-selectin level was a risk factor for DVT (OR 3.38, CI 1.180 - 9.780, p=0.02), while high NET level was also a risk factor for DVT (OR 2.88, CI 1.026-8.074, p=0.04).

Statistics:

  • The study involved 62 subjects, with 31 in each case and control groups.
  • The mean age of the case group was 50.26±12.15 years.
  • The mean age of the control group was 52.81±11.64 years.
  • High soluble P-selectin level was a risk factor for DVT (OR 3.38, CI 1.180 - 9.780, p=0.02).
  • High NET level was a risk factor for DVT (OR 2.88, CI 1.026-8.074, p=0.04).
  • Carboplatin was used by 71% of subjects in both the case and control groups.

Sources:

  • F1000Research. High Levels of Soluble P-selectin, Neutrophil Extracellular Traps, and Myeloperoxidase as Risk Factor of Deep Vein Thrombosis in Malignancy Patients Receiving Platinum-Based Chemotherapy [version 2; peer review: 2 approved, 1 approved with reservations]. F1000Research, 2025,13. (F1000Research - http://f1000research.com).
  • Ketut Suega, et al. High Levels of Soluble P-selectin, Neutrophil Extracellular Traps, and Myeloperoxidase as Risk Factor of Deep Vein Thrombosis in Malignancy Patients Receiving Platinum-Based Chemotherapy. Hematology Week. August 4, 2025; p 2419.