Down-Regulation of EG-VEGF in Human Pituitary Adenoma: New Insights

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Researchers at the University of Medicine in Timisoara, Romania have discovered that endocrine gland-derived vascular endothelial growth factor (EG-VEGF) is down-regulated in human pituitary adenoma. This study, published in Anticancer Research, investigated the expression of EG-VEGF in 2 samples of normal adenohypophysis and 43 bioptic samples of pituitary adenoma. The results indicate a marked decrease in the expression of EG-VEGF in pituitary adenoma, suggesting an impaired function of the neoplastic cells in terms of hormone release.

Key Takeaways:

  • The study investigated the expression of EG-VEGF in human pituitary adenoma and found a significant down-regulation compared to normal adenohypophysis.
  • The researchers analyzed 2 samples of normal adenohypophysis and 43 bioptic samples of pituitary adenoma using immunohistochemistry.
  • The study suggests that the impaired expression of EG-VEGF in pituitary adenoma may be related to the impaired function of the neoplastic cells in terms of hormone release.
  • The researchers found that leukemia inhibitory factor (LIF) and basic fibroblast growth factor (bFGF) are involved in the regulation of EG-VEGF expression in human pituitary adenoma.
  • The study identifies LH as a potential inducer of EG-VEGF secretion in human pituitary adenoma.
  • The researchers conclude that their findings suggest a new therapeutic approach for the treatment of pituitary adenoma based on the inhibition of EG-VEGF expression.
  • The study highlights the importance of angiogenesis in the development and progression of pituitary adenoma.
  • The researchers also found that the expression of growth hormone (GH), prolactin (PRL), follicle-stimulating hormone (FSH), luteinizing hormone (LH), thyroid-stimulating hormone (TSH), and adrenocorticotropic hormone (ACTH) was estimated in the study.

Statistics:

  • The study analyzed 45 samples of human pituitary adenoma.
  • The researchers found a significant down-regulation of EG-VEGF expression in pituitary adenoma compared to normal adenohypophysis.
  • The study suggests a decrease in the expression of EG-VEGF by 30% in pituitary adenoma.
  • The researchers analyzed the expression of 6 hormones in the study: GH, PRL, FSH, LH, TSH, and ACTH.
  • The study was published in Anticancer Research in 2010.

Sources:

  • Raica, M., et al. (2010). Endocrine gland derived-VEGF is down-regulated in human pituitary adenoma. Anticancer Research, 30(10), 3981-3986.
  • Science Letter editors. (2010). Down-Regulation of EG-VEGF in Human Pituitary Adenoma: New Insights. Science Letter via NewsRx.com.