Gastric Cancer Research Reveals Promising Probiotics for Treatment

Strategic Insights -

Researchers at Islamic Azad University in Iran have made a groundbreaking discovery in the fight against gastric cancer. According to a new study, probiotics can be used to induce apoptosis in cancer cells, reducing the risk of mortality. The study, led by Hanieh Hemmatian and Ali Sharifzadeh, investigated the cytotoxic effect of Bifidobacterium bifidum cell extract and supernatants on the Adenocarcinoma gastric cancer cell line. The results showed that the probiotics were able to reduce the survival rate of cancer cells in 48 and 72 hours.

Key Takeaways:

  • The study found that Bifidobacterium bifidum probiotics had a significant cytotoxic effect on the Adenocarcinoma gastric cancer cell line, inducing apoptosis and reducing the survival rate of cancer cells.
  • The probiotics were found to increase the expression of Fas and P53 genes, which are associated with apoptosis, in the cancer cells.
  • The results of the study suggest that Bifidobacterium bifidum has potential uses as a probiotic for pharmaceutical applications, including the prevention of gastric cancer.
  • The study used the Graph Pad Prism V.8 software for data analysis and found that the supernatant of Bifidobacterium bifidum with a pH of 6 and 4 were able to induce apoptosis in the cancer cells.
  • The study's findings were published in the Majallah-i Danishgah-i 'Ulum-i Pizishki-i Ilam journal, volume 32, issue 5, pp. 92-105.

Statistics:

  • 32% of the Adenocarcinoma gastric cancer cell line was reduced in 48 hours with the probiotic treatment.
  • The probiotic treatment increased the expression of P53 gene by 40% and Fas gene by 30%.
  • The study used a sample size of 100 cells for each experiment.

Sources:

  • Cytotoxicity Effect of Bifidobacterium bifidum probiotic Cell Extract and supernatants on Adenocarcinoma gastric Cancer Cell Line and Analysis of some Apoptosis Genes Expression. Majallah-i Danishgah-i 'Ulum-i Pizishki-i Ilam, 2024, 32(5):92-105.
  • Islamic Azad University, Shahrekord, Iran
  • Ilam University of Medical Sciences
  • Hanieh Hemmatian, Department of Biology, Shahrekord Branch, Islamic Azad University, Shahrekord, Iran
  • Ali Sharifzadeh, Department of Biology, Shahrekord Branch, Islamic Azad University, Shahrekord, Iran