Genetic Factors Linked to Fatty Liver Disease in Indian Population

Strategic Insights -

Research conducted by Charotar University of Science and Technology has shed light on the genetic factors contributing to fatty liver disease in the Indian population. The study investigated the association between single-nucleotide polymorphisms (SNPs) linked to non-alcoholic fatty liver disease (NAFLD) and liver steatosis in European and American adults of South Asian origin. The findings suggest that genetic variations in lyso-phospholipase like 1 (LYPLAL1) and tribble homolog 1 (TRIB1) are associated with the occurrence of NAFLD.

Key Takeaways:

  • The study identified 301 Indian adults with overweight or obesity, of which 155 participants had NAFLD, consisting of 58.7% males and 37.41% females.
  • The association between sex and body mass index (BMI) was found to be moderate, with P = 0.08.
  • An increase of 5 kg/m2 in BMI was associated with a 3.36 (95% CI, 1.90, 5.71) OR for males, and approximately 1.92 (95% CI, 1.40, 2.64) OR was estimated for women.
  • Adjusted models showed a statistically significant association of TRIB1 with hepatic steatosis (P = 0.04).
  • The study provides evidence for hereditary factors playing a significant role in the occurrence and progression of NAFLD.

Statistics:

  • 301 Indian adults were studied.
  • 155 participants had NAFLD.
  • 58.7% of participants with NAFLD were male.
  • 37.41% of participants with NAFLD were female.
  • An increase of 5 kg/m2 in BMI was associated with a 3.36 (95% CI, 1.90, 5.71) OR for males.
  • An increase of 5 kg/m2 in BMI was associated with approximately 1.92 (95% CI, 1.40, 2.64) OR for women.
  • Adjusted models showed a statistically significant association of TRIB1 with hepatic steatosis (P = 0.04).

Sources:

  • Discover Applied Sciences, 2025, 7(10):1-13.
  • A free version of this journal article is available at https://doi-org.sdpl.idm.oclc.org/10.1007/s42452-025-07243-3.
  • The publisher for Discover Applied Sciences is Springer.
  • NewsRx LLC, 2025, NewsRx.
  • Obesity & Diabetes Week, October 20, 2025; p 5.