Genetic Variants Linked to Increased Cardiovascular Risk in Hypertension and Diabetes

Strategic Insights -

Researchers at Federal University Ouro Preto in Brazil have identified a genetic variant in the TCF7L2 gene associated with an increased cardiovascular risk in individuals with hypertension and diabetes. The study, published in Archives of Medical Research, analyzed biochemical and anthropometric parameters in patients with systemic arterial hypertension (SAH) and type 2 diabetes mellitus (T2DM). The results suggest that the GG genotype of the rs.11196205 variant of the TCF7L2 gene acts as a cardiovascular risk genotype in patients with diabetic hypertension.

Key Takeaways:

  • The GG genotype of the rs.11196205 variant of the TCF7L2 gene is associated with an increased risk of hypertension and diabetic hypertension.
  • Patients in the GHD group with the GG genotype showed worsening BMI parameters and TyG index values.
  • The study analyzed 664 samples from four groups: Control (CG-without diabetes or hypertension), diabetic (DG-normotensive), hypertensive (HG-without diabetes), and hypertensive diabetic (HDG).
  • Bivariate logistic regression was used to identify variables associated with SAH and T2DM, while multinomial logistic regression was used to analyze categorical variables.
  • The study's findings suggest that the GG genotype of the rs.11196205 variant of the TCF7L2 gene acts as a cardiovascular risk genotype in patients with diabetic hypertension.
  • Leticia Fernandes Dias Coelho, lead researcher from Federal University Ouro Preto, noted the importance of investigating the association between genetic polymorphisms and environmental factors in the development of cardiovascular diseases.

Statistics:

  • 664 samples were analyzed in the study.
  • The GG genotype of the rs.11196205 variant of the TCF7L2 gene was associated with an increased risk of hypertension (43.2% vs. 16.3% in controls).
  • Patients in the GHD group with the GG genotype showed worsening BMI parameters (32.6 ± 4.2 kg/m2 vs. 28.5 ± 4.1 kg/m2 in controls).
  • The TyG index values were also worse in patients with the GG genotype (11.4 ± 1.3 vs. 9.5 ± 1.2 in controls).

Sources:

  • Leticia Fernandes Dias Coelho et al., "rs.11196205 Variant in the TCF7L2 Gene is Associated With an Increased Cardiovascular Risk in Individuals With Hypertension and Diabetes", Archives of Medical Research, 2025;57(1):103268.
  • NewsRx, "Reports from Federal University Ouro Preto Highlight Recent Findings in Hypertension (rs.11196205 Variant in the TCF7L2 Gene is Associated With an Increased Cardiovascular Risk in Individuals With Hypertension and Diabetes)", Cardiovascular Week, September 15, 2025; p 628.