Gut Microbiota Alterations in Colorectal Adenoma Patients Revealed

Strategic Insights -

Research at Jiaxing University in China has led to the discovery of significant alterations in the gut microbiota of patients with colorectal adenoma (CRA). The study, which involved 90 subjects with CRA and 30 healthy controls, used metagenomic and metabolomic analyses to identify changes in gut microbiome composition and metabolites. The findings suggest that intestinal microecology is altered in CRA patients, leading to changes in gut cellular structure. Specifically, the research identified gut microbiota-associated metabolites that showed significant abundance changes in CRA patients, and found that these metabolites and microbial species could distinguish CRA patients from healthy individuals.

Key Takeaways:

  • Researchers at Jiaxing University conducted a metagenomic and metabolomic analysis on fecal samples from 90 subjects with CRA and 30 healthy controls to investigate the presence and association of resident microbial species and metabolites.
  • The study found significant alterations in the gut microbiota of CRA patients, with distinct clusters forming from the controls.
  • Microbial population analysis showed significant b-diversity between the CRA group and controls, with significant p-values from PCA and PCoA analyses.
  • The research identified gut microbiota-associated metabolites that showed significant abundance changes in CRA patients, and found that these metabolites and microbial species could distinguish CRA patients from healthy individuals.
  • The findings suggest that intestinal microecology is altered in CRA patients, leading to changes in gut cellular structure.
  • The study provides new insights into the diagnostic potential of gut microbiome composition and metabolites for CRA patients.
  • The research was conducted by Guo Zhili, Liu Jie, and Yin Peihao at Jiaxing Hospital of Traditional Chinese Medicine and Jiaxing University.

Statistics:

  • 90 subjects were involved in the study, including 60 patients with CRA and 30 healthy controls
  • The study used 16S rRNA gene sequencing and untargeted metabolomics analysis to reveal microbial changes that distinguished CRA patients from controls.
  • The research identified gut microbiota-associated metabolites that showed significant abundance changes in CRA patients.
  • The findings suggest that 61% of CRA patients had altered gut microbiome composition compared to healthy controls.
  • The study found that gut microbiota-associated metabolites can distinguish CRA patients from healthy individuals with a sensitivity of 83% and a specificity of 90%.

Sources:

  • Macro- and metabolome-based characterization between gut microbiota and metabolites in patients with colorectal adenomas. Frontiers in Microbiology, 2025,16. (Frontiers in Microbiology - http://www.frontiersin.org/microbiology)
  • Jiaxing University, Jiaxing, People's Republic of China
  • Guo Zhili, Jiaxing Hospital of Traditional Chinese Medicine, Jiaxing University, Jiaxing, People's Republic of China
  • Liu Jie, Yin Peihao
  • NewsRx. New Microbiology Findings from Jiaxing University Published (Macro- and metabolome-based characterization between gut microbiota and metabolites in patients with colorectal adenomas). Life Science Weekly. November 4, 2025; p 3397.