Hepatitis B Virus Prevalence in Shanghai: New Findings

Strategic Insights -

A recent study conducted by researchers from the Shanghai Municipal Center for Disease Control and Prevention has shed light on the prevalence of hepatitis B virus (HBV) infection among community residents in Shanghai city. The study, published in Zhongguo gonggong weisheng, aimed to understand the effectiveness of HBV vaccination and provide evidence for optimizing current prevention and control strategies. The research team conducted serological surveys of HBV among community residents aged 1-69 years in Shanghai city in 2018 and 2020, collecting data on demographics, vaccination history, and HBV status.

Key Takeaways:

  • The study included 5,523 community residents in Shanghai city, with a positive rate of HBsAg at 3.95%, anti-HBs at 48.06%, and anti-HBc at 32.69%.
  • The positive rates of HBsAg and anti-HBc in the 5-29 age group were significantly lower than those in the 30-69 age group, indicating a decrease in HBV infection rates among younger individuals.
  • The study recommended continuing to strengthen HBV vaccination for newborns, vaccinating high-risk groups, and providing antiviral treatment for HBV-infected individuals in conjunction with surveillance efforts to contribute to the elimination of HBV.
  • The research team applied complex sampling weights to adjust the survey data and used Rao-Scott χ^2 tests for intergroup comparisons.
  • The study concluded that Shanghai city is transitioning from an intermediate HBV endemic area to a low endemic area.

Statistics:

  • 5,523 community residents in Shanghai city were included in the study.
  • The positive rate of HBsAg was 3.95%.
  • The positive rate of anti-HBs was 48.06%.
  • The positive rate of anti-HBc was 32.69%.
  • The age group 5-29 had significantly lower rates of HBsAg and anti-HBc compared to the 30-69 age group.
  • Shanghai city is transitioning from an intermediate to a low HBV endemic area.

Sources:

  • A seroepidemiological survey of hepatitis B among community residents in Shanghai city from 2018 to 2020. Zhongguo gonggong weisheng, 2025,41(8):943-948. Editorial Office of Chinese Journal of Public Health.
  • Data on Hepatitis B Virus Reported by Researchers at Shanghai Municipal Center for Disease Control and Prevention (A seroepidemiological survey of hepatitis B among community residents in Shanghai city from 2018 to 2020). Vaccine Weekly. October 15, 2025; p 601. NewsRx.