Highly Efficient Antimicrobial Agents Based on Sulfur-Enriched Molybdenum Disulfide Nano/Microparticles and Coatings

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Researchers from the Centre for Physical Sciences and Technology in Vilnius, Lithuania, have developed highly efficient antimicrobial agents based on sulfur-enriched, hydrophilic molybdenum disulfide nano/microparticles and coatings functionalized with palladium nanoparticles. The study, published in the Journal of Colloid and Interface Science, demonstrates the effectiveness of these agents in killing a range of pathogenic bacteria and yeast.

The researchers synthesized the molybdenum disulfide (MoS)-based nano/microparticles and coatings through a simple, one-step hydrothermal approach. The resulting materials exhibited prominent hydrophilic properties, which facilitated the interaction between the nanostructures and biomolecules. The study showed that the MoS-induced production of intracellular reactive oxygen species (ROS) was responsible for the antimicrobial activity.

The researchers tested the antimicrobial potential of the MoS-based nano/microparticles and coatings against a range of pathogens, including Salmonella enterica, Pseudomonas aeruginosa, Escherichia coli, methicillin-resistant Staphylococcus aureus (MRSA), Micrococcus luteus, and two Candida yeast strains. The results showed that the MoS-ns (40 mg mL) exhibited over 90% killing efficiency against S. aureus MRSA bacteria and both Candida yeast when exposed for 24 h.

Key Takeaways:

  • The researchers synthesized MoS-based nano/microparticles and coatings through a simple, one-step hydrothermal approach.
  • The resulting materials exhibited prominent hydrophilic properties, facilitating the interaction between the nanostructures and biomolecules.
  • The MoS-induced production of intracellular reactive oxygen species (ROS) was responsible for the antimicrobial activity of the nano/microparticles and coatings.
  • The researchers tested the antimicrobial potential of the MoS-based nano/microparticles and coatings against a range of pathogens, including Salmonella enterica, Pseudomonas aeruginosa, Escherichia coli, MRSA, Micrococcus luteus, and two Candida yeast strains.
  • The MoS-ns (40 mg mL) exhibited over 90% killing efficiency against S. aureus MRSA bacteria and both Candida yeast when exposed for 24 h.
  • Petal-like MoS microstructures and heterostructured MoS/Ti and Pd/MoS/Ti coatings also possessed high antimicrobial potential.
  • The study highlights the potential of these materials as antimicrobial agents in various applications.

Statistics:

  • The MoS-ns (40 mg mL) exhibited over 90% killing efficiency against S. aureus MRSA bacteria and both Candida yeast when exposed for 24 h.
  • The researchers tested the antimicrobial potential of the MoS-based nano/microparticles and coatings against 6 pathogens, including Salmonella enterica, Pseudomonas aeruginosa, Escherichia coli, MRSA, Micrococcus luteus, and two Candida yeast strains.
  • The MoS-based nano/microparticles and coatings were synthesized through a simple, one-step hydrothermal approach.
  • The resulting materials exhibited prominent hydrophilic properties, facilitating the interaction between the nanostructures and biomolecules.

Sources:

  • Vaclovas Klimas et al. (2021). Highly efficient antimicrobial agents based on sulfur-enriched, hydrophilic molybdenum disulfide nano/microparticles and coatings functionalized with palladium nanoparticles. Journal of Colloid and Interface Science, 591, 115-128.
  • NewsRx. (2021). Data on Nanoparticles Reported by Vaclovas Klimas and Colleagues (Highly efficient antimicrobial agents based on sulfur-enriched, hydrophilic molybdenum disulfide nano/microparticles and coatings functionalized with palladium nanoparticles). Nanotechnology Weekly. March 1, 2021; p 557.