IL-1RN and IL-4 Gene Polymorphisms Identified as Potential Genetic Markers for Bladder Cancer Susceptibility

Strategic Insights -

Researchers from Cukurova University conducted a case-control study to investigate the relationship between the distribution of IL-1RN, TNF-beta, and IL-4 polymorphism and the clinical features of bladder cancer. The study included 100 patients with bladder carcinoma and 102 healthy control subjects. The researchers identified the IL-1RN, IL-4, and TNF-beta gene polymorphisms through PCR restriction fragment length polymorphism-based analysis and compared the allelic frequencies between patients and control groups.

Key Takeaways:

  • The IL-1RN and IL-4 gene polymorphisms were found to have significantly different allele distribution frequencies between patients with bladder carcinoma and healthy control subjects.
  • The TNF-beta gene polymorphism did not show statistically significant differences between the two groups.
  • The IL-1RN and IL-4 gene polymorphisms were not associated with tumor stage, histopathological grade, tumor size/number, and smoking condition in the patient group.
  • However, the allele distribution of the IL-4 gene was significantly different considering histopathological grades in both smoking and total patients group.
  • The IL-4 gene polymorphism was identified as a potential genetic marker of susceptibility to bladder cancer.
  • The researchers concluded that the development of more sensitive and specific tests for genetic polymorphisms of cytokines that are effective on inflammation could lead to clinical improvements in diagnosis, treatment, and prognosis of bladder carcinoma.

Statistics:

  • 100 patients with bladder carcinoma participated in the study.
  • 102 healthy control subjects were enrolled in the study.
  • The IL-1RN and IL-4 gene polymorphisms had significantly different allele distribution frequencies between patients and control groups (p 0.05).
  • The IL-4 gene polymorphism was associated with histopathological grades in both smoking and total patients group (p < 0.05).

Sources:

  • "The IL-1RN and IL-4 gene polymorphisms are potential genetic markers of susceptibility to bladder cancer: a case-control study." World Journal of Urology, 2015;33(3):389-395.
  • World Journal of Urology. (www.springerlink.com/content/0724-4983/)
  • Cukurova University, Fac Med, Dept. of Biostat, Adana, Turkey.