Interleukin-17A and Interleukin-17F Gene Polymorphisms and Hepatitis B Virus-Related Hepatocellular Carcinoma Risk in a Chinese Population

Strategic Insights -

Research conducted by X.E. Xi and colleagues at the First Affiliated Hospital of Guangxi Medical University in China has explored the relationship between interleukin (IL)-17A and IL-17F gene polymorphisms and the risk of hepatitis B virus (HBV)-related hepatocellular carcinoma (HCC). The study included 155 patients with HBV-related HCC and 171 healthy controls, and genotypes were determined by polymerase chain reaction-restriction fragment length polymorphism and DNA sequencing. The findings revealed that the ACA haplotype was associated with an increased risk of HCC (odds ratio 1.820, 95% confidence interval 1.181-2.624, P = 0.013), while the GCG haplotype was associated with a significantly decreased risk of HBV-related HCC (odds ratio 0.454, 95% confidence interval 0.112-0.898, P = 0.035). These results suggest that IL-17A rs4711998, IL-17A rs2275913, and IL-17F rs763780 polymorphisms do not contribute to HBV-related HCC susceptibility independently, but rather the ACA and GCG haplotypes in the IL-17 gene might be a risk factor and a protective marker, respectively, for HBV-related HCC in a Chinese population.

Key Takeaways:

  • The study included 155 patients with HBV-related HCC and 171 healthy controls, with genotypes determined by polymerase chain reaction-restriction fragment length polymorphism and DNA sequencing.
  • The ACA haplotype was associated with an increased risk of HCC (odds ratio 1.820, 95% confidence interval 1.181-2.624, P = 0.013).
  • The GCG haplotype was associated with a significantly decreased risk of HBV-related HCC (odds ratio 0.454, 95% confidence interval 0.112-0.898, P = 0.035).
  • The IL-17A rs4711998, IL-17A rs2275913, and IL-17F rs763780 polymorphisms do not contribute to HBV-related HCC susceptibility independently.
  • The ACA and GCG haplotypes in the IL-17 gene might be a risk factor and a protective marker, respectively, for HBV-related HCC in a Chinese population.
  • The study provides insights into the molecular mechanisms underlying HBV-related HCC and highlights the potential role of IL-17 gene polymorphisms in the development of this disease.

Statistics:

  • The study included 155 patients with HBV-related HCC and 171 healthy controls.
  • The ACA haplotype was associated with an increased risk of HCC with an odds ratio of 1.820 (95% confidence interval 1.181-2.624, P = 0.013).
  • The GCG haplotype was associated with a significantly decreased risk of HBV-related HCC with an odds ratio of 0.454 (95% confidence interval 0.112-0.898, P = 0.035).

Sources:

  • Xi, X.E., Liu, Y., Lu, Y., Huang, L., Qin, X., & Li, S. (2015). Interleukin-17A and interleukin-17F gene polymorphisms and hepatitis B virus-related hepatocellular carcinoma risk in a Chinese population. Medical Oncology, 32(1), 355.