Manipulation of Cellular DNA Damage Repair Machinery Facilitates Propagation of Human Papillomaviruses

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Human papillomaviruses (HPV) interact with cellular DNA damage repair (DDR) pathways to facilitate their propagation. According to research from the Fred Hutchinson Cancer Research Center, these interactions can be divided into two broad categories. The first category involves HPV proteins that activate DDR pathways, such as ATM and ATR, to recruit repair proteins to viral replication centers. However, this activation can elicit a cell cycle arrest that hampers the viral lifecycle. To counteract this, HPV proteins like E6 and E7 prevent the DDR response from pausing cell cycle progression or inducing apoptosis.

Key Takeaways:

  • The interplay between HPV and DDR pathways can promote or inhibit viral propagation.
  • HPV proteins like E1 and E2 activate DDR pathways to recruit repair proteins to viral replication centers.
  • Activation of DDR pathways by HPV proteins can elicit a cell cycle arrest that hampers the viral lifecycle.
  • HPV proteins like E6 and E7 prevent the DDR response from pausing cell cycle progression or inducing apoptosis.
  • The interactions between HPV and DDR proteins are crucial for facilitating HPV propagation.
  • A detailed account of these interactions is provided in the research, Man­Ipu­la­tion of ceU­lar DNA damage repair machin­ery facilitates propagation of human papillomaviruses.
  • The research suggests that HPV proteins can manipulate cellular mechanisms to favor their replication and propagation.

Statistics:

  • The propagation of human papillomaviruses is both promoted and inhibited by DDR proteins.
  • The ATM and ATR pathways are activated by HPV proteins like E1 and E2.
  • The p53 signaling pathway is inhibited by HPV proteins like E6 and E7.
  • The research reported in Seminars In Cancer Biology provides a detailed account of the interactions between HPV and DDR proteins.
  • The downside of this manipulation is the potential for cancer development (no specific statistics given).

Sources:

  • Manipulation of cellular DNA damage repair machinery facilitates propagation of human papillomaviruses. Seminars In Cancer Biology, 2014;26():30-42. (Elsevier - www.elsevier.com; Seminars In Cancer Biology - www.elsevier.com/wps/product/cws_home/622943)
  • N.A. Wallace, Division of Human Biology, Fred Hutchinson Cancer Research Center, Seattle, WA, United States