Menstrual Cycle Affects Glycemic Control in Adolescents with Type 1 Diabetes

Strategic Insights -

A recent study has shed light on the impact of the menstrual cycle on glycemic control in adolescent females with type 1 diabetes. The research, conducted at Cairo University, found that the hormonal variation during the menstrual cycle significantly affects the need for basal insulin dose adjustments in young women with type 1 diabetes. The study's findings suggest that individualized basal insulin dose adjustment can prevent worsening of glycemic control and diabetic ketoacidosis during menses.

Key Takeaways:

  • The study involved 78 adolescent females with type 1 diabetes, with a median age of 17.3 years and a median duration of type 1 diabetes of 7 years.
  • The median age at menarche was 13 years, and 48 (61.5%) of the patients required modification of their basal insulin dose during the days of menstrual bleeding.
  • Forty-four patients required an increase in their basal insulin by a mean of 10% of their usual dose, while 4 required a decrease in their basal dose by a mean of 9%.
  • The remaining 30 (38.5%) patients did not require any change in their basal insulin during the days of menstrual bleeding.
  • The research concluded that individualized basal insulin dose adjustment can prevent worsening of glycemic control and diabetic ketoacidosis during menses.
  • The study's findings have significant implications for the management of type 1 diabetes in adolescent females, particularly during the menstrual cycle.

Statistics:

  • 78 adolescent females with type 1 diabetes were involved in the study.
  • The median age of the participants was 17.3 years.
  • The median age at menarche was 13 years.
  • 48 (61.5%) of the patients required modification of their basal insulin dose during the days of menstrual bleeding.
  • The increase in basal insulin dose increased by a mean of 10% of the usual dose for 44 patients.
  • The decrease in basal dose decreased by a mean of 9% for 4 patients.

Sources:

  • Assessment of the Menstrual Cycle and Its Effect on Glycemic Control in a Sample of Egyptian Adolescent Females with Type 1 Diabetes: A Clinical Prospective Study. Clinical Diabetology, 2024,13(4).
  • Clinical Diabetology: https://journals.viamedica.pl/diabetologia_kliniczna/index
  • Via Medica: publisher for Clinical Diabetology.
  • doi-org.sdpl.idm.oclc.org: 10.5603/cd.100092.
  • Diabetes, Endocrine, and Metabolism Pediatric Unit, Pediatric Department, Cairo University, Egypt.