No Association Between COVID-19 Vaccines and Ischemic Stroke Found in New Research

Strategic Insights -

According to a comprehensive study published in the Journal of the Neurological Sciences, there is no association between COVID-19 vaccines and an increased risk of ischemic stroke. The research analyzed data from the National COVID Cohort Collaborative (N3C) database, which included 119,275 patients who suffered ischemic stroke between February 2021 and April 2023.

Key Takeaways:

  • The study found no association between mRNA or adenovirus COVID-19 vaccines and ischemic stroke.
  • The research included 119,275 patients who suffered ischemic stroke between February 2021 and April 2023.
  • The study used the Self-Controlled Case Series (SCCS) method to estimate the association between multiple vaccine-type-dose combinations and risk of incident ischemic stroke.
  • The researchers found elevated risk of incident ischemic stroke following first doses of BNT162b2, mRNA1273, and Ad26.COV2·S vaccine types, but no significant results emerged for bivalent vaccines.
  • The study concluded that the results indicate no association between mRNA or adenovirus COVID-19 vaccines and ischemic stroke.
  • The research was peer-reviewed and included input from authors Kristen Hansen, Steve R. Makkar, Nathan Hotaling, and Hythem Sidky.

Statistics:

  • The study included 119,275 patients who suffered ischemic stroke.
  • The researchers analyzed data from the National COVID Cohort Collaborative (N3C) database.
  • The study found elevated risk of incident ischemic stroke following first doses of BNT162b2 (IRR = 1.42, 95 % CI: 1.24-1.62), mRNA1273 (IRR = 1.37, 95 % CI: 1.16-1.62), and Ad26.COV2·S (IRR = 1.40, 95 % CI: 1.08-1.81) vaccine types.
  • The researchers found no significant results emerged for bivalent vaccines.

Sources:

  • NewsRx. Findings from National Center for Advancing Translational Sciences in the Area of COVID-19 Described (Electronic health record analysis reveals no association between COVID-19 vaccines and ischemic stroke). Information Technology Newsweekly. October 28, 2025; p 45.
  • Journal of the Neurological Sciences. Electronic health record analysis reveals no association between COVID-19 vaccines and ischemic stroke. 2025;478:123681.
  • Elsevier. Radarweg 29, 1043 Nx Amsterdam, Netherlands.