Rare Case of Tuberculous Aneurysm Diagnosed in Pregnant Woman Due to Drug-Induced Liver Injury from TB Treatment

Strategic Insights -

A rare case of bilateral multiple lower limb tuberculous aneurysms was diagnosed in a pregnant woman due to drug-induced liver injury resulting from tuberculosis (TB) treatment, according to a new study published in Jurnal Respirasi. The patient, a 27-year-old woman at 14-15 weeks of gestation, was found to have painless lumps on her left side of her neck and both ankles, which were confirmed to be tuberculous aneurysms through fine needle aspiration biopsy and vascular Doppler ultrasound. The patient underwent surgical intervention, followed by resumption of anti-TB treatment, leading to the resolution of the pseudoaneurysms by the fifth month of treatment.

Key Takeaways:

  • A rare case of bilateral multiple lower limb tuberculous aneurysms was diagnosed in a pregnant woman due to drug-induced liver injury resulting from TB treatment.
  • The patient's symptoms included painless lumps on her left side of her neck and both ankles, which were confirmed to be tuberculous aneurysms through fine needle aspiration biopsy and vascular Doppler ultrasound.
  • The patient underwent surgical intervention, followed by resumption of anti-TB treatment, leading to the resolution of the pseudoaneurysms by the fifth month of treatment.
  • Tuberculous aneurysm in pregnant patients with TB is a rare and potentially life-threatening condition, difficult to diagnose, but TB infection should be considered a possible cause in endemic countries.
  • Surgery combined with anti-TB treatment improves outcomes in patients with tuberculous aneurysm.
  • The patient was treated with category one anti-TB drug (ATD) therapy, which was resumed after surgical intervention.
  • Elevated bilirubin levels were observed in the patient, with a measured level of 3.76 mg/dL after one month of category one anti-TB drug therapy.

Statistics:

  • The patient was 27 years old and at 14-15 weeks of gestation when diagnosed with bilateral multiple lower limb tuberculous aneurysms.
  • The patient underwent surgical intervention, followed by resumption of anti-TB treatment, leading to the resolution of the pseudoaneurysms by the fifth month of treatment.
  • Elevated bilirubin levels were observed in the patient, with a measured level of 3.76 mg/dL after one month of category one anti-TB drug therapy.

Sources:

  • Bilateral Multiple Lower Limb Tuberculous Aneurysms in a Pregnant Woman with Drug-Induced Liver Injury due to Tuberculosis Treatment. Jurnal Respirasi, 2025,11(3):256-262.
  • NewsRx. New Findings Reported from University of Airlangga Describe Advances in Drug-Induced Liver Injury (Bilateral Multiple Lower Limb Tuberculous Aneurysms in a Pregnant Woman with Drug-Induced Liver Injury due to Tuberculosis Treatment). TB & Outbreaks Week. October 21, 2025; p 2096.