Renin-Angiotensin-Aldosterone System Tied to Renal Cell Cancer Risk

Strategic Insights -

Researchers have investigated the relationship between the renin-angiotensin-aldosterone system (RAAS) and the risk of renal cell cancer (RCC). According to a study, polymorphisms in RAAS genes, specifically in AGT, AGTR1, and ACE, were found to be associated with RCC risk. The study, conducted in the Netherlands, used data from the Netherlands Cohort Study, which included 120,852 participants aged 55 to 69 years. The researchers found that SNPs in AGTR1 were associated with RCC risk, with AGTR1_rs1492078 (AA vs. GG) decreasing RCC risk and AGTR1_rs5186 (CC vs. AA) increasing RCC risk. The effects of these SNPs were modified by hypertension, suggesting a potential link between RAAS and RCC etiology.

Key Takeaways:

  • Polymorphisms in RAAS genes, specifically in AGT, AGTR1, and ACE, were found to be associated with RCC risk.
  • SNPs in AGTR1, particularly AGTR1_rs1492078 (AA vs. GG) and AGTR1_rs5186 (CC vs. AA), were associated with RCC risk.
  • The effects of these SNPs were modified by hypertension, suggesting a potential link between RAAS and RCC etiology.
  • The Netherlands Cohort Study, which included 120,852 participants aged 55 to 69 years, was used to investigate the relationship between RAAS and RCC risk.
  • The study found that sodium intake was differentially associated with RCC risk across genotypes of several SNPs.
  • The research suggests that RAAS may be a candidate pathway in RCC etiology, with potential implications for prevention and treatment.

Statistics:

  • The Netherlands Cohort Study included 120,852 participants aged 55 to 69 years.
  • The study observed 503 RCC cases over a 20.3-year follow-up period.
  • The hazard ratio (HR) for RCC risk associated with AGTR1_rs1492078 (AA vs. GG) was 0.70 (95% CI: 0.49-1.00).
  • The HR for RCC risk associated with AGTR1_rs5186 (CC vs. AA) was 1.49 (95% CI: 1.08-2.05).

Sources:

  • Polymorphisms in genes of the renin-angiotensin-aldosterone system and renal cell cancer risk: Interplay with hypertension and intakes of sodium, potassium and fluid. International Journal of Cancer, 2015;136(5):1104-1116.
  • Wiley-Blackwell, 111 River St, Hoboken 07030-5774, NJ, USA. (Wiley-Blackwell - www.wiley.com/; International Journal of Cancer - onlinelibrary.wiley.com/journal/10.1002/(ISSN)1097-0215)