Research Highlights Advancements in Circulating Tumor DNA for Colon Cancer

Strategic Insights -

A recent study published in Discover Oncology aims to map the research landscape on circulating tumor DNA (ctDNA) for colorectal cancer. The study collected articles and reviews from the Web of Science Core Collection and Scopus databases, conducting bibliometric analysis and visualization using VOSviewer, CiteSpace, and R packages. The analysis revealed significant advancements and emerging trends in the clinical application of ctDNA for colon cancer. Key findings include the United States and China leading in publication volume, with 555 and 306 papers, respectively, and the University of Texas MD Anderson Cancer Center being the most prolific institution.

Key Takeaways:

  • The study collected a total of 1,730 publications on ctDNA and colorectal cancer from the Web of Science Core Collection and Scopus databases.
  • The United States and China led in publication volume, with 555 and 306 papers, respectively.
  • The University of Texas MD Anderson Cancer Center was the most prolific institution, with the most publications on ctDNA and colorectal cancer.
  • The journals Cancers and Frontiers in Oncology were the most frequently published, with 235 and 197 publications, respectively.
  • Bardelli A stood out as the most prolific and cited author, with 35 publications and 1,141 citations.
  • Cluster analysis revealed trending topics such as 'minimal residual disease,' 'adjuvant chemotherapy,' and 'recurrence.'
  • The identified hotspots deserve further attention from researchers in this field.

Statistics:

  • 1,730 publications were included in the bibliometric analysis (Source: Discover Oncology).
  • 555 papers were published by institutions in the United States (Source: Discover Oncology).
  • 306 papers were published by institutions in China (Source: Discover Oncology).
  • The University of Texas MD Anderson Cancer Center had the highest publication volume (Source: Discover Oncology).
  • Bardelli A had 35 publications (Source: Discover Oncology).
  • Bardelli A had 1,141 citations (Source: Discover Oncology).
  • 235 publications were in the journal Cancers (Source: Discover Oncology).
  • 197 publications were in the journal Frontiers in Oncology (Source: Discover Oncology).

Sources:

  • Discover Oncology, 2025;16(1):1575. "Research trends and prospects of Circulating tumor DNA associated with colorectal cancer: a bibliometric analysis"
  • Affiliated Hospital of North Sichuan Medical College, Second Dept. of Gastrointestinal Surgery, Nanchong, Sichuan, People's Republic of China. "Research trends and prospects of Circulating tumor DNA associated with colorectal cancer: a bibliometric analysis"
  • Springer, One New York Plaza, Suite 4600, New York, Ny, United States. "Discover Oncology"