Resveratrol Induces Apoptosis in Multidrug-Resistant Lung Cancer Cells

Strategic Insights -

Research published in the Oncology Reports journal has found that resveratrol, a compound found in red wine and several other plant-based foods, can induce apoptosis in multidrug-resistant human lung cancer cells. The study, conducted by W. Zhao and colleagues from the Chinese PLA General Hospital, Department of Respiratory Medicine, involved treating human multidrug-resistant SPC-A-1/CDDP cells with resveratrol at different concentrations.

The researchers observed that resveratrol significantly inhibited the proliferation of SPC-A-1/CDDP cells, induced apoptosis, and arrested the cell cycle phase. Additionally, resveratrol decreased the IC50 values of multiple chemotherapeutic drugs, demonstrating its anti-tumor effects. The study also found that resveratrol affected the proliferation of SPC-A-1/CDDP cells in a dose- and time-dependent manner, and down-regulated the expression of survivin, a protein that plays a key role in cancer cell survival.

Key Takeaways:

  • Resveratrol treatment significantly inhibited the proliferation of SPC-A-1/CDDP cells at concentrations of 25, 50, or 100 micromolars.
  • Resveratrol induced apoptosis in SPC-A-1/CDDP cells, with a significant increase in apoptosis ratio after treatment.
  • The cell cycle phase distribution was also affected by resveratrol treatment, with cells arrested at the G0-G1 and S phase or at the G2/M phase.
  • Resveratrol decreased the IC50 values of cisplatin, gefitinib, and paclitaxel, demonstrating its anti-tumor effects.
  • The expression of survivin in SPC-A-1/CDDP cells decreased after resveratrol treatment.
  • Resveratrol had a significant effect on survivin expression, with a dose-dependent decrease in survivin levels.
  • The study also found that resveratrol affected the proliferation of SPC-A-1/CDDP cells in a dose- and time-dependent manner.

Statistics:

  • The study used 25, 50, or 100 micromolar concentrations of resveratrol in in vitro studies.
  • In vivo studies used a special diet that included resveratrol at a dose of either 1 g/kg/day or 3 g/kg/day.
  • No adverse toxicological effects of resveratrol treatment were observed in the study.
  • Resveratrol treatment significantly increased apoptosis ratio in SPC-A-1/CDDP cells by 50% after 24 hours.

Sources:

  • Zhao, W., et al. "Resveratrol down-regulates survivin and induces apoptosis in human multidrug-resistant SPC-A-1/CDDP cells." Oncology Reports, vol. 23, no. 1, 2010, pp. 279-86.
  • Drug Resistance.