Risk Factors for Bone Metastasis in Prostate Cancer Revealed in New Research

Strategic Insights -

New research has identified several key risk factors for bone metastasis in patients with prostate cancer, including prostate-specific antigen (PSA), Gleason score, percentage of monocyte (M%), and N stage. The study, conducted by a team of researchers from Bengbu Medical University, analyzed data from 177 patients who had undergone radical prostatectomy and found that 18.64% (33/177) exhibited bone metastasis. The researchers also confirmed their findings using data from the Surveillance, Epidemiology, and End Results (SEER) database, which consisted of 96,497 patients.

Key Takeaways:

  • The study identified PSA, Gleason score, M%, and N stage as independent risk factors for bone metastasis in prostate cancer patients.
  • The analysis of data from the SEER database confirmed that PSA, Gleason score, and N stage were independent risk factors for bone metastasis.
  • The researchers found that the sensitivities for PSA and Gleason score were 66.67% and 69.70%, respectively, while the specificities were 85.42% and 65.97%, respectively.
  • The study also found a positive correlation between the primary histological grade and the rate of bone metastasis.
  • The researchers suggested that further exploration is needed to investigate the significance of M% and primary histological grade in the diagnosis of bone metastasis in PCa.

Statistics:

  • 18.64% (33/177) of patients with prostate cancer exhibited bone metastasis.
  • PSA and Gleason score had sensitivities of 66.67% and 69.70%, respectively, and specificities of 85.42% and 65.97%, respectively.
  • Data from the SEER database consisted of 96,497 patients.
  • The primary histological grade showed a significant positive correlation with the rate of bone metastasis.
  • 177 patients were included in the analysis from Bengbu Medical University.

Sources:

  • Risk factors for bone metastasis in patients with prostate cancer: a retrospective study based on single-center data and SEER database. Chinese Clinical Oncology, 2025;14(2):16.
  • Tao Zhou, Graduate School of Bengbu Medical University, Bengbu, People's Republic of China.
  • Xuechun Hu, Zongpan Ke, Ping Xiang, Jun Xiao, Changming Wang, and Yixun Liu (co-authors).
  • NewsRx. Data on Prostate Cancer Reported by Tao Zhou and Colleagues (Risk factors for bone metastasis in patients with prostate cancer: a retrospective study based on single-center data and SEER database). Information Technology Newsweekly. May 20, 2025; p 137.