Rutgers Study Finds Certain Mouthrinses Can Help Block Coronavirus Infection

Strategic Insights -

Researchers at the Rutgers School of Dental Medicine have discovered that two types of mouthrinses can disrupt coronavirus disease (COVID-19) transmission. Listerine and chlorhexidine gluconate were found to effectively block the virus infection in tissue cultures without causing toxic effects on cells. This study is significant as it highlights the potential of mouthrinses in reducing the spread of COVID-19. According to Theresa Chang, co-author and associate professor, "viruses require live cells to replicate. If tested agents kill cells (cytotoxicity), viruses cannot replicate."

Key Takeaways:

  • Listerine and chlorhexidine gluconate were found to be effective in blocking COVID-19 transmission without toxic effects on cells.
  • The researchers tested Colgate Peroxyl and povidone-iodine, but found that they had a strong toxic effect on cells.
  • Mouthrinses can interfere with viral activity in several ways, including changing the spike protein configuration and affecting the viral cell envelope.
  • The researchers distinguished between virus-induced cytotoxicity and agent-induced cytotoxicity, providing a clearer understanding of the effect of mouthrinses on viruses and cells.
  • The study sheds light on potential applications in dentist offices, where mask-wearing is not optimal.
  • Daniel Fine, senior author, emphasized the importance of understanding the antiviral potential of mouthrinses.

Statistics:

  • The researchers tested the effect of mouthrinses on virus replication and ensured there would be no toxic effect.
  • The study showed that Listerine and chlorhexidine gluconate were effective at concentrations that would mimic actual use.
  • The researchers diluted the mouthwashes to concentrations that would mimic actual use, as reported by Rutgers Today.
  • The study involved testing the effect of mouthrinses on virus replication and ensured there was no toxic effect, as stated by Theresa Chang.
  • The researchers diluted the mouthwashes to concentrations that would mimic actual use, as reported in the article from Rutgers Today.

Sources:

  • Rutgers study finds certain mouthrinses can potentially help block coronavirus infection [KWKithmy Wickramasinghe] Mar 31, 2021
  • Rutgers Today, "Rutgers researchers investigate the antiviral potential of mouthrinses"
  • Theresa Chang, Associate Professor, Department of Microbiology, Biochemistry and Molecular Genetics