Sternal Bursitis in Poultry: New Research Uncovers Diverse Population of Escherichia coli Bacteria

Strategic Insights -

Researchers from the University of Tras-os-Montes and Alto Douro have conducted a comprehensive study on sternal bursitis in broiler chickens, revealing a diverse population of Escherichia coli bacteria. The study, published in Veterinary Sciences, found that the bacteria exhibit resistance to multiple antibiotics, including tetracycline and ciprofloxacin. Furthermore, the researchers identified virulence-associated genes per isolate, suggesting a strong pathogenic potential.

Key Takeaways:

  • The study characterized 36 isolates recovered from sternal bursitis in broiler chickens, using phenotypic antimicrobial susceptibility testing, PCR-based screening, and whole genome sequencing.
  • The genetic analysis revealed a diverse population of 15 sequence types, including ST155, ST201, and ST58, with resistance to tetracycline and ciprofloxacin being common.
  • Chromosomal mutations associated with quinolone and fosfomycin resistance were also identified.
  • WGS revealed a high number of virulence-associated genes per isolate, particularly those linked to adhesion, secretion systems, and iron acquisition.
  • The researchers found that many isolates harbored virulence markers typical of ExPEC/APEC, even in the absence of multidrug resistance.
  • The study highlights the need for including sternal bursitis in genomic surveillance programs and emphasizes the importance of integrated One Health approaches.

Statistics:

  • 36 isolates were recovered from sternal bursitis in broiler chickens.
  • 15 sequence types were identified, including ST155, ST201, and ST58.
  • 58-96 virulence-associated genes were found per isolate.
  • 50% of the isolates exhibited resistance to tetracycline.
  • 40% of the isolates exhibited resistance to ciprofloxacin.
  • Chromosomal mutations were identified in 10% of the isolates.

Sources:

  • Genomic Analysis of Antibiotic Resistance and Virulence Profiles in Escherichia coli Linked to Sternal Bursitis in Chickens: A One Health Perspective. Veterinary Sciences, 2025;12(7).
  • University of Tras-os-Montes and Alto Douro. MicroART-Microbiology and Antibiotic Resistance Team.
  • Mdpi, St Alban-Anlage 66, Ch-4052 Basel, Switzerland.
  • NewsRx. University of Tras-os-Montes and Alto Douro Reports Findings in Veterinary Medicine (Genomic Analysis of Antibiotic Resistance and Virulence Profiles in Escherichia coli Linked to Sternal Bursitis in Chickens: A One Health Perspective). Veterinary Week. August 4, 2025; p 149.