Universities and colleges
Researchers at Northeastern University have prepared and studied DNA and RNA oligonucleotides with formacetal internucleoside linkages between uridine and adenosine nucleosides. Their results, published in the Journal of the American Chemical Society, reveal that formacetal modifications have distinct effects on the stability of double helical RNA and DNA. While the
Universities and colleges
Scientists in the United States have developed novel strategies to attach DNA arrays to the surfaces of cells, enabling specific labeling and delivery of materials to cell surfaces. The research uses biotin-streptavidin interactions and antibody-cell surface interactions to bind DNA architectures to biotinylated cells and cancer cells, respectively. This breakthrough
American Chemical Society
Researchers from the University of California have used phase-sensitive sum-frequency vibrational spectroscopy (PS-SFVS) to study the isotopically diluted water/vapor interface. The study, published in the Journal of the American Chemical Society, provided new insights into the structure and properties of the interface. The researchers found that the Im x(
American Chemical Society
Scientists at the University of California have discovered a novel DNA-DDAB complex film that exhibits a structural switching transition as it is dried or wetted with water. The film, prepared by forming a complex between DNA phosphate groups and the surfactant DDAB, undergoes a phase transition from single-stranded DNA to
Universities and colleges
In a recent study, investigators from South Korea have reported that methylation of DNA plays a regulatory role in DNA metabolism. The researchers found that the Escherichia coli DNA adenine methyltransferase methylates the N6 positions of adenines in the sequence 5'-GATC-3', which exists in the fully methylated
Scientists
Scientists at Michigan State University have identified a 10-O-acetyltransferase in Taxus cuspidata that regiospecifically transfers short-chain alkanoyl groups to the C10 hydroxyl of 10-deacetylbaccatin III. This enzyme, along with five others on the paclitaxel (Taxol) biosynthetic pathway, was screened for 4-O-acetyltransferase activity against 4-deacetylbaccatin III derivatives. The researchers found that
Scientists
Researchers from the University of California have developed a new method to selectively target protein kinases in cell lysates, which could lead to significant advances in understanding the complex interactions between enzymes and substrates. By creating a three-component chemical reaction that covalently cross-links the kinase-substrate complex, the team was able
Universities and colleges
Researchers from Johns Hopkins University, led by H. Ding, have made a groundbreaking discovery in the field of DNA chemistry. By using phenylselenyl-modified thymidine, they have identified a new mechanism for producing DNA interstrand cross-links (ICLs) via two distinct pathways: photolysis and oxidation. This finding sheds new light on the
